1. Membrane Transporter/Ion Channel
  2. Potassium Channel
  3. Glipizide-d11

Glipizide-d11  (Synonyms: 格列吡嗪 d11)

目录号: HY-B0254S
产品使用指南

Glipizide-d11 是 Glipizide 的氘代物。Glipizide (CP 2872; K 4024) 是一种有效的、具有口服活性的磺酰脲类抗糖尿病试剂 (anti-diabetic agent),可用于 2 型糖尿病的研究,但不适用于1 型糖尿病。Glipizide 通过部分阻断郎格汉斯胰岛细胞中 ATP 敏感钾通道 (KATP) 发挥作用。

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Glipizide-d<sub>11</sub> Chemical Structure

Glipizide-d11 Chemical Structure

CAS No. : 1189426-07-0

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  • 生物活性

  • 纯度 & 产品资料

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生物活性

Glipizide-d11 is the deuterium labeled Glipizide. Glipizide (CP 2872; K 4024) a potent, orally active and sulfonylurea class anti-diabetic agent and can be used for type 2 diabetes mellitus research but not type 1. Glipizide acts by partially blocking ATP-sensitive potassium (KATP) channels among β cells of pancreatic islets of Langerhans[1][2].

体外研究
(In Vitro)

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

456.60

Formula

C21H16D11N5O4S

CAS 号
中文名称

格列吡嗪 d11

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献
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