2. GPCR/G Protein Neuronal Signaling Metabolic Enzyme/Protease
  3. Adrenergic Receptor Phosphodiesterase (PDE)
  4. GS-5759

GS-5759 既是一种 β₂-肾上腺素受体 (β₂-adrenergic receptor) 激动剂，也是一种 PDE4 抑制剂。GS-5759 通过激活 β₂ 受体增加细胞内 cAMP 水平，促进支气管扩张。GS-5759 抑制 PDE4 活性，减少 cAMP 降解，增强抗炎作用。GS-5759 在动物模型中展现出强效支气管扩张能力和抗炎能力。GS-5759 可用于研究慢性阻塞性肺疾病 (COPD) 等呼吸系统疾病。

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GS-5759

GS-5759 Chemical Structure

CAS No. : 1346653-91-5

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GS-5759 相关抗体

Top Publications Citing Use of Products

查看 Adrenergic Receptor 亚型特异性产品:

查看所有亚型
α adrenergic receptor β adrenergic receptor

查看 Phosphodiesterase (PDE) 亚型特异性产品:

查看所有亚型
PDE1 PDE2 PDE3 PDE4 PDE5 PDE6 PDE7 PDE9 PDE10 PDE11 PDE12 PDE8 Autotaxin

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

GS-5759 is both a β₂-adrenergic receptor agonist and a PDE4 inhibitor. GS-5759 increases intracellular cAMP levels by activating the β₂ receptor, promoting bronchial dilation. GS-5759 inhibits PDE4 activity, reduces cAMP degradation, and enhances anti-inflammatory effects. GS-5759 exhibits potent bronchial dilation and anti-inflammatory capabilities in animal models. GS-5759 can be used for research on respiratory diseases such as chronic obstructive pulmonary disease (COPD)[1][2].

IC50 & Target[1]

PDE4

 

β2 adrenoceptor

 

分子量

850.94

Formula

C47H42N6O8S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

GS-5759 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

GS-57591346653-91-5GS5759GS 5759Adrenergic ReceptorPhosphodiesterase (PDE)Beta ReceptorBifunctional moleculePDE4 inhibitorLong-acting beta2-adrenoceptor agonistCOPDAnti-inflammatoryBronchodilatorForced proximityInhibitorinhibitorinhibit

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HY-120246
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