1. Membrane Transporter/Ion Channel
  2. Sodium Channel Potassium Channel
  3. GsAF-I

GsAF-I 是一种有效的 NavhERG1 通道阻滞剂,对 Nav1.1、Nav1.2、Nav1.3、Nav1.4、Nav1.6、Nav1.7 和 hERG1 的 IC50 分别为 0.36、0.6、1.28、0.33、1.2、0.04 和 4.8 μM。

MCE 的所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

Custom Peptide Synthesis

GsAF-I Chemical Structure

GsAF-I Chemical Structure

1.  客户无需承担相应的运输费用。

2.  同一机构(单位)同一产品试用装仅限申领一次,同一机构(单位)一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户

规格 是否有货
50 mg   询价  
100 mg   询价  
250 mg   询价  

* Please select Quantity before adding items.

Customer Review

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

GsAF-I is a potent Nav and hERG1 channels blocker with IC50s of 0.36, 0.6, 1.28, 0.33, 1.2, 0.04 and 4.8 μM against Nav1.1, Nav1.2, Nav1.3, Nav1.4, Nav1.6, Nav1.7 and hERG1, respectively[1].

IC50 & Target

IC50: 0.04 μM (Nav1.7), 0.33 μM (Nav1.4), 0.36 μM (Nav1.1), 0.6 μM (Nav1.2), 1.2 μM (Nav1.6), 1.28 μM (Nav1.3), 4.8 μM (hERG1)[1]

分子量

3708.39

Formula

C160H244N46O42S7

Sequence

Tyr-Cys-Gln-Lys-Trp-Leu-Trp-Thr-Cys-Asp-Ser-Glu-Arg-Lys-Cys-Cys-Glu-Asp-Met-Val-Cys-Arg-Leu-Trp-Cys-Lys-Lys-Arg-Leu-NH2 (Disulfide bridge:Cys2-Cys16;Cys9-Cys21;Cys15-Cys25)

Sequence Shortening

YCQKWLWTCDSERKCCEDMVCRLWCKKRL-NH2 (Disulfide bridge:Cys2-Cys16;Cys9-Cys21;Cys15-Cys25)

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献
  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称:

 

* 需求量:

* 客户姓名:

 

* Email:

* 电话:

 

* 公司或机构名称:

   留言给我们:

Bulk Inquiry

Inquiry Information

产品名称:
GsAF-I
目录号:
HY-P5795
需求量: