Gum arabic  (Synonyms: 阿拉伯胶; Arabic gum)

Gum Arabic is an orally active complex branched polysaccharide. Gum Arabic can be isolated from the Acacia senegal tree. Gum Arabic upregulates the expression of maturation markers (CD86, CD40, and CD54), promotes ERK1/2 phosphorylation, and inhibits Apoptosis. Gum Arabic exhibits antimalarial effects against Plasmodium berghei ANKA. Gum Arabic exhibits hepatoprotective, renal, and cardiovascular protective activities. Gum Arabic improves obesity. Gum Arabic is commonly used as a stabilizer and thickener. Gum Arabic can be used in the research of brain tumor imaging^{[1][2][3][4][5][6][7][8][9][10]}.

Gum arabic (0.5%；24 h) 上调小鼠骨髓来源的树突状细胞 (DC) 中成熟标志物 (CD86、MHCII、CD40、CD54) 的表达^[6]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Gum arabic (100 g/L；通过饮用水口服；连续 5 天) 显著降低 Acetaminophen (HY-66005) 诱导的雄性瑞士白化小鼠的肝毒性^[1]。
Gum arabic (2.5%-10.0%；通过饮用水口服；连续 8 天) 不会显著改变大鼠体内自由基清除剂 (GSH、AA、SOD) 的浓度或脂质过氧化^[2]。
Gum arabic (3-6 g/100 mL；通过饮用水口服；连续 5 周) 无法有效逆转慢性肾衰竭大鼠 (肾残余模型) 的体重下降或降低升高的肌酐和尿素水平^[2]。
Gum arabic (10%；通过饮用水口服；感染前 10 天开始服用) 可略微降低感染伯氏疟原虫 ANKA 的 SV129/J 野生型小鼠的寄生虫血症，并显著延长其寿命^[5]。
Gum arabic (15% w/v；通过饮用水口服；4 周) 可减轻雄性 CD1 小鼠腺嘌呤诱发的慢性肾病 (CKD)，其方式是减少十二指肠炎症、氧化和亚硝化应激，并改善肾功能 (降低血浆尿素、肌酐和尿白蛋白)^[8]。
Gum arabic (15% w/v；通过饮用水口服) 可改善 water-pipe smoke (WPS) 诱发的 C57BL/6 小鼠心血管毒性，包括减少血栓形成、降低收缩压、抑制心脏炎症和氧化应激，并防止心肌 DNA 损伤和细胞凋亡^[9]。
Gum arabic (10% w/w；通过饮食口服；12 周) 通过降低体重、内脏脂肪组织 (VAT) 重量、血糖和血浆脂质 (总胆固醇、LDL、VLDL) 以及调节肝脏脂质代谢相关基因来抑制高脂饮食诱发的小鼠肥胖^[10]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

200-300

9000-01-5

固体

Off-white to light yellow

阿拉伯胶

Room temperature in continental US; may vary elsewhere.

-20°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

• [1]. Protective effect of arabic gum against acetaminophen-induced hepatotoxicity in mice. Pharmacological Research. Volume 48, Issue 6, December 2003, Pages 631-635.

  [2]. Ali BH , et al. Biological effects of gum arabic: a review of some recent research. Food Chem Toxicol. 2009 Jan;47(1):1-8.  [Content Brief]

  [3]. Gilerovitch HG, et al. The use of electron microscopic immunocytochemistry with silver-enhanced 1.4-nm gold particles to localize GAD in the cerebellar nuclei. J Histochem Cytochem. 1995 Mar;43(3):337-43.  [Content Brief]

  [4]. Anderson D M W, et al. The safety of gum arabic as a food additive and its energy value as an ingredient: a brief review. Journal of Human Nutrition and Dietetics, 1989, 2(3): 137-144.

  [5]. Ballal A, et al. Anti-malarial effect of gum arabic. Malar J. 2011 May 20;10:139.  [Content Brief]

  [6]. Xuan NT, et al. Stimulation of mouse dendritic cells by Gum Arabic. Cell Physiol Biochem. 2010;25(6):641-8.  [Content Brief]

  [7]. Zhang L, et al. Gum arabic-coated magnetic nanoparticles for potential application in simultaneous magnetic targeting and tumor imaging. AAPS J. 2009 Dec;11(4):693-9.  [Content Brief]

  [8]. Ali BH, et al. Gum arabic reduces inflammation, oxidative, and nitrosative stress in the gastrointestinal tract of mice with chronic kidney disease. Naunyn Schmiedebergs Arch Pharmacol. 2020 Aug;393(8):1427-1436.  [Content Brief]

  [9]. Nemmar A, et al. Gum Arabic Ameliorates Impaired Coagulation and Cardiotoxicity Induced by Water-Pipe Smoke Exposure in Mice. Front Physiol. 2019 Feb 25;10:53.  [Content Brief]

  [10]. Ahmed A A, et al. Gum arabic suppressed diet-induced obesity by alteration the expression of mRNA levels of genes involved in lipid metabolism in mouse liver. Bioactive carbohydrates and dietary fibre, 2016, 7(1): 15-20.