2. Metabolic Enzyme/Protease
  3. Carbonic Anhydrase
  4. hCAIX-IN-8

hCAIX-IN-8 (compound 7i) 是一种有效的选择性 hCAIX 抑制剂，CAII、CAIX、CAVA 的IC50s 分别为 1.99, 0.024, 1.10 µM。hCAIX-IN-8 具有低毒性的抗增殖活性。hCAIX-IN-8 减少上皮细胞向间充质细胞的转化并诱导细胞凋亡 (apoptosis)。hCAIX-IN-8 抑制细胞迁移和定植。

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hCAIX-IN-8 Chemical Structure

hCAIX-IN-8 Chemical Structure

CAS No. : 2414633-40-0

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hCAIX-IN-8 相关抗体

Top Publications Citing Use of Products

查看 Carbonic Anhydrase 亚型特异性产品:

查看所有亚型
CA CA I CA Ⅱ CA Ⅸ CA XII

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

hCAIX-IN-8 (compound 7i) is a potent and selective hCAIX inhibitor with IC50s of 1.99, 0.024, 1.10 µM for CAII, CAIX, CAVA respectively. hCAIX-IN-8 shows anti-proliferation activity with low toxicity. hCAIX-IN-8 decreases the epithelial to mesenchymal transitions and induces apoptosis. hCAIX-IN-8 inhibits cell migration and colonization potential[1].

IC50 & Target

IC50: 1.99 µM (CAII); 0.024 (CAIX), 1.10 µM (CAVA)[1]
体外研究
(In Vitro)

hCAIX-IN-8 (compound 7i) shows anti-proliferation activity with IC50是of 8.44, 11.22 µM for HT29, HepG2 cells, respectively[1].
hCAIX-IN-8 induces apoptosis in 24.44% and 19.22% of HT29 and HepG2 cells, respectivelysup>[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

hCAIX-IN-8 相关抗体:
分子量

396.35

Formula

C19H16N4O6
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

hCAIX-IN-8 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

hCAIX-IN-82414633-40-0Carbonic AnhydraseCarbonate dehydrataselow toxicityHEK293apoptosisHT29HepG2 cellsmigrationanti-proliferationInhibitorinhibitorinhibit

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目录号：
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