2. Metabolic Enzyme/Protease Vitamin D Related/Nuclear Receptor Cell Cycle/DNA Damage
  3. 17β-HSD PPAR
  4. HSD17B13/PPAR modulator-1

HSD17B13/PPAR modulator-1 (Compound 17) 是一种 HSD17B13/PPAR 的多靶点调节剂，HSD17B13/PPAR modulator-1 是 HSD17B13 抑制剂，其 IC50 为 0.91 μM。HSD17B13/PPAR modulator-1 是 PPAR 激动剂，对 PPARα、PPARδ 和 PPARγ 的 EC50 值分别为 1.55、0.12 和 0.01 μM。HSD17B13/PPAR modulator-1 在代谢功能障碍相关脂肪性肝炎 (MASH) 模型中能显著改善肝功能、调节脂质代谢、改善纤维化、发挥抗氧化和抗炎作用。HSD17B13/PPAR modulator-1 可用于研究 MASH。

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HSD17B13/PPAR modulator-1

HSD17B13/PPAR modulator-1 Chemical Structure

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HSD17B13/PPAR modulator-1 相关抗体

Top Publications Citing Use of Products

查看 PPAR 亚型特异性产品:

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PPARα PPARβ/δ PPARγ PPAR PPARδ

  • 生物活性

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  • 参考文献

生物活性

HSD17B13/PPAR modulator-1 (Compound 17) is a HSD17B13/PPAR multitarget modulator. HSD17B13/PPAR modulator-1 is an inhibitor of HSD17B13, with its IC50 value being 0.91 μM. HSD17B13/PPAR modulator-1 is a PPAR agonist, with the EC50 values for PPARα, PPARδ, and PPARγ being 1.55, 0.12, and 0.01 μM respectively. HSD17B13/PPAR modulator-1 can significantly improve liver function, regulate lipid metabolism, alleviate fibrosis, and exert antioxidant and anti-inflammatory effects in the model of metabolic dysfunction-related steatohepatitis (MASH). HSD17B13/PPAR modulator-1 can be used for the study of MASH[1].

IC50 & Target[1]

PPARα

1.55 μM (EC50)

PPARδ

0.12 μM (EC50)

PPARγ

0.01 μM (EC50)

分子量

598.63

Formula

C31H29F3N2O5S
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

HSD17B13/PPAR modulator-1 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

HSD17B13/PPAR modulator-117β-HSDPPAR17beta-HSD17β-hydroxysteroid dehydrogenases17 beta-hydroxysteroid dehydrogenasePeroxisome proliferator-activated receptorsSD17B13multitarget modulatormetabolic dysfunction-associated steatohepatitis (MASH)compound 17Inhibitorinhibitorinhibit

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产品名称：
HSD17B13/PPAR modulator-1
目录号：
HY-179015
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