Hydrostatin-TL1  (Synonyms: H-TL1)

Hydrostatin-TL1 (H-TL1), a nine-amino-acid peptide, is a TNF-α antagonist. Hydrostatin-TL1 can be isolated from the venom gland of sea snake Hydrophis cyanocinctus. H-TL1 competitively inhibits the interaction between TNF-α/TNFR1 and attenuates the cytotoxicity and inflammation of TNF-α. Hydrostatin-TL1 can be used for TNF-α-associated inflammatory diseases, such as rheumatoid arthritis, osteoporosis and inflammatory bowel disease (IBD) research^[1].

Hydrostatin-TL1 (1-1000 nM，18-20 小时) 以浓度依赖性方式抑制 TNF-α 诱导的 L929 细胞死亡^[1]。
Hydrostatin-TL1 (0.2-1.6 μM) 显著抑制 HEK-293 细胞中 TNF-α 诱导的 NF-κB 和 MAPKs 信号通路中 p38、ERK、JNK 和 IκB 蛋白磷酸化^[1]。
Hydrostatin-TL1 无法抑制 IL-1β 诱导的 HEK-293 细胞中 IκB 的磷酸化^[1]。
Hydrostatin-TL1 (0.1-0.8 nM) 以剂量依赖性方式降低 HEK-293 细胞中 TNF-α 介导的促炎因子 mRNA 表达 (IL-8、TNF-α、ICAM-1 和 VCAM-1) ^[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Hydrostatin-TL1 (0.5-1 mg/kg，腹腔注射，每日一次，连续7-8天) 对 DSS (HY-116282C) 诱导的急性结肠炎小鼠模型具有显著的抗炎活性^[1]。
Hydrostatin-TL1 (20-80 μg/kg，分别于 1、3 和 5 小时给药三次) 剂量依赖性地降低 LPS (HY-D1056) 诱导的急性休克小鼠模型的死亡率^[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

934.11

C₃₉H₇₁N₁₁O₁₃S

2243975-43-9

Ala-Thr-Ser-Lys-Pro-Ser-Leu-Lys-Cys

ATSKPSLKC

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Wang N, et al. Hydrostatin-TL1, an Anti-Inflammatory Active Peptide from the Venom Gland of Hydrophis cyanocinctus in the South China Sea. Int J Mol Sci. 2016 Nov 22;17(11):1940.  [Content Brief]