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    Stem Cell/Wnt
    JAK/STAT Signaling
  2. JAK
  3. JAK-2/3-IN-1

JAK-2/3-IN-1 

目录号: HY-10652
产品使用指南

JAK-2/3-IN-1 是一种有效的 JAK-2JAK-3 抑制剂,详细信息请参考专利文献 US8163732B2 中的化合物 46。

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JAK-2/3-IN-1 Chemical Structure

JAK-2/3-IN-1 Chemical Structure

CAS No. : 1036241-36-7

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

JAK-2/3-IN-1 is a potent JAK-2 and JAK-3 inhibitor extracted from patent US8163732B2, compound 46, has Kis of <250 nM for both isoforms[1].

IC50 & Target[1]

JAK2

<250 nM (Ki)

JAK3

<250 nM (Ki)

体外研究
(In Vitro)

The Janus kinases (JAK) are a family of tyrosine kinases that play a critical role in cytokine signaling. The family consists of JAK-1, JAK-2, JAK-3 and TYK-2, and the down-stream substrates of this family of kinases include the signal transducer and activator of transcription (STAT) proteins. JAK/STAT signaling has been implicated in the mediation of many abnormal immune responses, such as allergies and asthma; autoimmune diseases; as well as in solid and hematologic malignancies[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

345.78

Formula

C20H12ClN3O

CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

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产品名称:
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目录号:
HY-10652
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