2. GPCR/G Protein Neuronal Signaling Immunology/Inflammation
  3. Histamine Receptor
  4. JNJ-5207852 dihydrochloride

JNJ-5207852 dihydrochloride 是组胺 H3 受体有选择性的有效拮抗剂，其对大鼠和人类 H3 受体的 pKi 值分别为 8.9，9.24。

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JNJ-5207852 dihydrochloride Chemical Structure

JNJ-5207852 dihydrochloride Chemical Structure

CAS No. : 1782228-76-5

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Other Forms of JNJ-5207852 dihydrochloride:

JNJ-5207852 dihydrochloride 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

JNJ-5207852 dihydrochloride is a selective and potent histamine H3 receptor (H3R) antagonist, with pKis of 8.9, 9.24 for rat and human H3R, respectively.

IC50 & Target[1]

H3 Receptor

8.9 (pKi, for rat)

H3 Receptor

9.24 (pKi, for human)

体内研究
(In Vivo)

JNJ-5207852 (1-10mg/kg s.c.) increases time spent awake and decreases REM sleep and slow-wave sleep, but fails to have an effect on wakefulness or sleep in H3 receptor knockout mice. The wake promoting effects of this H3 receptor antagonist are not associated with hypermotility. A 4-week daily treatment of mice with JNJ-5207852 (10 mg/kg i.p.) does not lead to a change in body weight. JNJ-5207852 is extensively absorbed after oral administration and reaches high brain levels[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male, Sprague-Dawley rats weighing 282-334 g[1].
Dosage: 3, 10, 30 mg/kg.
Administration: S.C.
Result: Iincreased time spent awake and decreased REM sleep and slow-wave sleep.
分子量

389.40

Formula

C20H34Cl2N2O
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

JNJ-5207852 dihydrochloride 相关分类

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  • Do most proteins show cross-species activity?

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Keywords:

JNJ-52078521782228-76-5JNJ5207852JNJ 5207852Histamine ReceptorlowtoxicityREMsleepInhibitorinhibitorinhibit

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HY-12190A
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