2. Immunology/Inflammation Apoptosis
  3. COX Apoptosis
  4. Ketorolac

Ketorolac  (Synonyms: 酮咯酸; RS37619)

目录号: HY-B0580 纯度: 99.93%
COA 产品使用指南

摩尔计算器

Ketorolac (RS37619) 是一种非甾体抗炎剂，为非选择性的 COX 抑制剂，对 COX-1 和 COX-2 的 IC50 值分别为 20 nM 和 120 nM。Ketorolac被用作 0.5% 滴眼液，用于过敏性结膜炎、黄斑囊状水肿、术中瞳孔缩小、术后眼炎疼痛的研究。Ketorolac 也是一种 DDX3 抑制剂，可用于癌症的研究。

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Ketorolac Chemical Structure

Ketorolac Chemical Structure

CAS No. : 74103-06-3

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规格 价格 是否有货 数量
50 mg ￥350
In-stock
100 mg ￥490
In-stock
200 mg   询价  
500 mg   询价  

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Other Forms of Ketorolac:

Ketorolac 相关抗体

Top Publications Citing Use of Products

查看 COX 亚型特异性产品:

查看所有亚型
COX COX-1 COX-2 COX-3

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Ketorolac (RS37619) is a non-steroidal anti-inflammatory drug (NSAID), acting as a nonselective COX inhibitor, with IC50s of 20 nM for COX-1 and 120 nM for COX-2. Ketorolac tromethamine is used as 0.5% ophthalmic solution for the research of allergic conjunctivitis, cystoid macular edema, intraoperative miosis, and postoperative ocular inflammation and pain. Ketorolac tromethamine is also a DDX3 inhibitor that can be used for cancer research[1][4].

IC50 & Target[1]

COX-1

20 nM (IC50)

COX-2

120 nM (IC50)

DDX3

 

体外研究
(In Vitro)

Ketorolac (RS37619) salt (0-30 μM; 48 h) effectively kills the oral cancer cells[4].
Ketorolac salt (0-5 μM; 48 h) inhibits the expression of DDX3 protein, and induces apoptosis in H357 cells[4].
Ketorolac salt (0-2.5 μM; 0-16 h) inhibits the proliferation of oral cancer cells[4].
Ketorolac salt (0-50 μM) directly interacts with DDX3 and inhibits the ATPase activity[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Ketorolac 相关抗体:

Cell Viability Assay[4]

Cell Line: HOK, SCC4, SCC9 and H357 cells
Concentration: 0-30 μM
Incubation Time: 48 h
Result: Showed inhibition with IC50s of 2.6, 7.1 and 8.1 μM against H357, SCC4 and SCC9 cells, respectively. And the normal HOK cell line did not show any cell death effect.

Cell Proliferation Assay[4]

Cell Line: H357
Concentration: 0.5, 1.0, 1.5, 2.0 and 2.5 μM
Incubation Time: 0, 8 and 16 h
Result: Inhibited the proliferation.

Western Blot Analysis[4]

Cell Line: H357
Concentration: 1, 2.5 and 5 μM
Incubation Time: 48 h
Result: Significantly reduced DDX3 protein expression levels, but not completely ablated as compared to DMSO treated cells. Up regulated the expression of E-cadherin.

Apoptosis Analysis[4]

Cell Line: H357
Concentration: 2.5 and 5 μM
Incubation Time: 48 h
Result: Induced apoptosis.
体内研究
(In Vivo)

Ketorolac (RS37619) (0.4% ketorolac tromethamine ophthalmic solution) shows powerful ocular anti-inflammatory activities in rabbits[1].
Ketorolac (4 mg/kg/day, p.o.; 2 weeks) has no detrimental effect in the volume fraction of bone trabeculae formed inside the alveolar socket in rats[2].
Ketorolac (60 μg; intrathecal injection; once) attenuates the damage caused by spinal cord ischemia in rats[3].
Ketorolac salt (20 and 30 mg/kg; i.p.; two times in a week for 3 weeks) reduces oral carcinogenesis in mice[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: New Zealand White rabbits (2.0–2.7 kg), LPS endotoxin-induced ocular inflammation[1]
Dosage: 50 μL ketorolac tromethamine ophthalmic solution 0.4%
Administration: In eyes, twice, 2 hours and 1 hour before LPS challenge
Result: Resulted in a nearly complete inhibition (98.7%) of LPS endotoxin-induced increases in FITC (fluorescein isothiocyanate)-dextran in the anterior chamber, and resulted in a nearly complete inhibition (97.5%) of LPS endotoxin-induced increases in aqueous PGE2 concentrations in the aqueous humor.
Animal Model: Male Wistar rats (400–450 g), spinal cord ischemia model[3]
Dosage: 30 and 60 μg
Administration: Intrathecal injection, 1 h before the ischemia induction for once
Result: Significantly reduced the motor disturbances and improved the survival rate at 60 μg.
Animal Model: Significantly reduced the motor disturbances and improved the survival rate at 60 μg.
Dosage: 20 mg/kg and 30 mg/kg
Administration: IP injection, two times in a week for 3 weeks
Result: Decreased tumor burden, reduced expression of DDX3 and anti-apoptotic proteins (Bcl-2 and Mcl-1).
Clinical Trial
分子量

255.27

Formula

C15H13NO3
CAS 号
性状

固体

颜色

White to light yellow

中文名称

酮咯酸；酮洛酸
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶解性数据
In Vitro: 

DMSO 中的溶解度 : 250 mg/mL (979.36 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 3.9174 mL 19.5871 mL 39.1742 mL
5 mM 0.7835 mL 3.9174 mL 7.8348 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料
参考文献

Ketorolac 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.9174 mL 19.5871 mL 39.1742 mL 97.9355 mL
5 mM 0.7835 mL 3.9174 mL 7.8348 mL 19.5871 mL
10 mM 0.3917 mL 1.9587 mL 3.9174 mL 9.7936 mL
15 mM 0.2612 mL 1.3058 mL 2.6116 mL 6.5290 mL
20 mM 0.1959 mL 0.9794 mL 1.9587 mL 4.8968 mL
25 mM 0.1567 mL 0.7835 mL 1.5670 mL 3.9174 mL
30 mM 0.1306 mL 0.6529 mL 1.3058 mL 3.2645 mL
40 mM 0.0979 mL 0.4897 mL 0.9794 mL 2.4484 mL
50 mM 0.0783 mL 0.3917 mL 0.7835 mL 1.9587 mL
60 mM 0.0653 mL 0.3265 mL 0.6529 mL 1.6323 mL
80 mM 0.0490 mL 0.2448 mL 0.4897 mL 1.2242 mL
100 mM 0.0392 mL 0.1959 mL 0.3917 mL 0.9794 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Ketorolac74103-06-3RS37619酮咯酸酮洛酸RS 37619RS-37619COXApoptosisCyclooxygenaseallergic conjunctivitiscystoid macular edemaintraoperative miosispostoperative ocularinflammationophthalmic solutionnon-steroidal anti-inflammatory drugNSAIDovarian canceranticanceroral cancerInhibitorinhibitorinhibit

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