L-Ascorbic acid (GMP Like)  (Synonyms: L-Ascorbate (GMP Like); Vitamin C (GMP Like))

L-Ascorbic acid (GMP Like) is the GMP Like class L-Ascorbic acid (HY-B0166). L-Ascorbic acid (L-Ascorbate, Vitamin C), an electron donor, is an endogenous antioxidant agent. L-Ascorbic acid inhibits selectively Ca_v3.2 channels with an IC₅₀ of 6.5 μM. L-Ascorbic acid is also a collagen deposition enhancer and an elastogenesis inhibitor^[1][2][3]. L-Ascorbic acid exhibits anti-cancer effects through the generation of reactive oxygen species (ROS) and selective damage to cancer cells^[4].

L-Ascorbic acid 的抗癌作用由钠依赖性维生素 C 转运蛋白 2 (SVCT-2) 决定，它是 L-Ascorbic acid 的转运蛋白。L-Ascorbic acid (0.1 μM-2 mM) 根据 SVCT-2 表达和 L-ascorbic acid 摄取表现出抗癌作用。人结直肠癌细胞系对 L-Ascorbic acid 表现出不同的反应，这主要取决于 SVCT-2 的表达水平^[4]。
L-Ascorbic acid (10 μg/ml, 5 d) 增强小鼠成纤维细胞向IPSCs的重编程^[5]。
L-Ascorbic acid (50 μg/ml, 9 d) 促进成纤维细胞转化为心肌细胞^[6]。
L-Ascorbic acid (50 ng/ml, 4-6 d) 促进小鼠的终末分化 B 细胞生成全能 IPS 细胞^[7]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

L-Ascorbic acid/Tolbutamide 在正常 (60 mg/kg) 和糖尿病 (40 mg/kg) 条件下以剂量依赖性方式产生降血糖活性。在 L-Ascorbic acid 存在的情况下，与 Tolbutamide 匹配对照相比，Tolbuatmide (20 mg/kg) 起效早且维持时间更长^[5]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

176.12

C₆H₈O₆

50-81-7

固体

White to off-white

Room temperature in continental US; may vary elsewhere.

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

• [1]. Michael T Nelson, et al. Molecular mechanisms of subtype-specific inhibition of neuronal T-type calcium channels by ascorbate. J Neurosci. 2007 Nov 14;27(46):12577-83.  [Content Brief]

  [2]. Aleksander Hinek, et al. Sodium L-ascorbate enhances elastic fibers deposition by fibroblasts from normal and pathologic human skin. J Dermatol Sci. 2014 Sep;75(3):173-82.  [Content Brief]

  [3]. Sungrae Cho, et al. Hormetic dose response to L-ascorbic acid as an anti-cancer drug in colorectal cancer cell lines according to SVCT-2 expression. Sci Rep. 2018 Jul 27;8(1):11372.  [Content Brief]

  [4]. Satyanarayana Sreemantula, et al. Influence of antioxidant (L- ascorbic acid) on tolbutamide induced hypoglycaemia/antihyperglycaemia in normal and diabetic rats. BMC Endocr Disord. 2005 Mar 3;5(1):2.  [Content Brief]

  [5]. Sebastian J Padayatty, et al. Vitamin C as an antioxidant: evaluation of its role in disease prevention. J Am Coll Nutr. 2003 Feb;22(1):18-35.  [Content Brief]

  [6]. Esteban MA, Wang T, Qin B, et al. Vitamin C enhances the generation of mouse and human induced pluripotent stem cells. Cell Stem Cell. 2010;6(1):71-79. doi:10.1016/j.stem.2009.12.001  [Content Brief]

  [7]. Talkhabi M, Pahlavan S, Aghdami N, Baharvand H. Ascorbic acid promotes the direct conversion of mouse fibroblasts into beating cardiomyocytes. Biochem Biophys Res Commun. 2015;463(4):699-705.  [Content Brief]

  [8]. Stadtfeld M, Apostolou E, Ferrari F, et al. Ascorbic acid prevents loss of Dlk1-Dio3 imprinting and facilitates generation of all-iPS cell mice from terminally differentiated B cells. Nat Genet. 2012;44(4):398-S2.  [Content Brief]