2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. iGluR
  4. Lanicemine

Lanicemine  (Synonyms: 拉尼西明; AZD6765)

目录号: HY-108235
COA 产品使用指南

摩尔计算器

Lanicemine (AZD6765) 是一种低捕获的 NMDA 受体拮抗剂，Ki 为 0.56-2.1 μM。CHO 和爪蟾卵母细胞中，IC50 分别为 4-7 μM 和 6.4 μM。具有抗抑郁作用。

在相同的摩尔浓度下，化合物盐形式与游离形式有相同的生物活性，但盐形式 Lanicemine dihydrochloride 通常具有更好的水溶性和稳定性。

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Lanicemine Chemical Structure

Lanicemine Chemical Structure

CAS No. : 153322-05-5

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Lanicemine 的其他形式现货产品:

Customer Review

Other Forms of Lanicemine:

Lanicemine 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Lanicemine (AZD6765) is a low-trapping NMDA channel blocker (Ki of 0.56-2.1 μM for NMDA receptor; IC50s of 4-7 μM and 6.4 μM in CHO and Xenopus oocyte cells, respectively). Antidepressant effects[1].

IC50 & Target

NMDA receptor[1]
体外研究
(In Vitro)

Lanicemine 相关抗体:

Cell Line:
Concentration:
Incubation Time:
Result:
体内研究
(In Vivo)

Lanicemine produces sustained antidepressant efficacy with minimal psychotomimetic adverse effects[1]. Lanicemine (3, 10 or 30 mg/kg; intraperitoneal) not only engages brain circuits involved in the generation of gamma- electroencephalography (EEG), but also influences these networks independent of the broader systems-level disruptions typical of ketamine[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Sprague-Dawley rats[1]
Dosage: 3, 10 or 30 mg/kg
Administration: Intraperitoneal
Result: Produced pronounced dose-dependent elevations in spontaneous gamma-band EEG, but only gamma changes for Ketamine were tightly coupled to increases in locomotor activity.
Clinical Trial
分子量

198.26

Formula

C13H14N2
CAS 号
性状

液体

颜色

Colorless to light yellow

中文名称

拉尼西明
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Pure form -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
纯度 & 产品资料

纯度: ≥99.0%

COA (263 KB)

产品使用指南 (1538 KB)
参考文献

Lanicemine 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Lanicemine153322-05-5AZD6765拉尼西明AZD 6765AZD-6765iGluRIonotropic glutamate receptorsAntidepressantefficacylanicemineNMDAchannelblockerInhibitorinhibitorinhibit

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