1. Immunology/Inflammation
  2. Toll-like Receptor (TLR)
  3. Lipopolysaccharides, from Salmonella typhosa

Lipopolysaccharides, from Salmonella typhosa  (Synonyms: LPS, from bacterial (Salmonella typhosa))

目录号: HY-D1056B4
产品使用指南 技术支持

Lipopolysaccharides, from Salmonella typhosa 是来源于伤寒沙门氏菌 (Salmonella typhosa) 的脂多糖内毒素和 TLR-4 激活剂,是一种 S 型 LPS,可激活免疫系统的致病相关分子模式 (PAMP) 和诱导细胞分泌迁移体。Lipopolysaccharides, from Salmonella typhosa 具有典型的 3 部分结构:O 抗原、核心寡糖和脂质 A。Lipopolysaccharides, from Salmonella typhosa 可作为疫苗佐剂,并在体内免疫反应中具有针对 B 细胞的佐剂活性。
建议配制 ≥2 mg/mL 母液,并保证充分混合溶解。由于 LPS 具有吸附特性,分装保存时需使用低吸附离心管

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Lipopolysaccharides, from Salmonella typhosa Chemical Structure

Lipopolysaccharides, from Salmonella typhosa Chemical Structure

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规格 价格 是否有货 数量
5 mg ¥2450
1 - 2 周
10 mg   询价  
50 mg   询价  

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查看 Toll-like Receptor (TLR) 亚型特异性产品:

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Lipopolysaccharides, from Salmonella typhosa are lipopolysaccharide endotoxins and TLR-4 activators derived from Salmonella typhosa, classified as S-type LPS, which can activate pathogen-associated molecular patterns (PAMP) of the immune system and induce cellular secretion of migrasomes. Lipopolysaccharides, from Salmonella typhosa exhibit a typical three-part structure: O-antigen, core oligosaccharide, and lipid A. Lipopolysaccharides, from Salmonella typhosa can serve as vaccine adjuvants and demonstrate adjuvant activity targeting B cells in immune responses in vivo[1].
It is recommended to prepare a stock solution of ≥2 mg/mL and ensure that it is fully mixed and dissolved. Due to the adsorption characteristics of LPS, low adsorption centrifuge tubes should be used for aliquoting and storage.

IC50 & Target

TLR-4[2]

体外研究
(In Vitro)

Note:
1. 为了保持 LPS 的完整性,建议将 LPS 溶液存放在硅烷化容器中。因为 LPS 可以粘附在塑料和某些类型的玻璃上,尤其是在浓度低于 0.1 mg/mL 时。如果 LPS 浓度超过 1 mg/mL,这种吸附作用相对较小,建议配制 ≥2 mg/mL 母液,并保证充分混合溶解。如果使用玻璃容器,请确保使用前充分混合至少 30 分钟,以重新溶解任何吸附在管壁的 LPS。
2. LPS 是一种能在溶液中形成不同尺寸胶束的分子,分子量不固定,储备液及工作液可直接配制成质量浓度 (mg/mL, μg/mL, etc.)
3. LPS 溶于水或 PBS 后可能会观察到均匀的浑浊溶液,如需过滤除菌,请勿直接过滤储备液,建议稀释成工作液之后用 0.22 μm 的滤膜过滤除菌

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献
  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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产品名称:
Lipopolysaccharides, from Salmonella typhosa
目录号:
HY-D1056B4
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