2. Cell Cycle/DNA Damage
  3. CDK
  4. LZ9

LZ9 是一种 ATP 竞争性 CDK1 和 CDK2 抑制剂。LZ9 具有用于结直肠癌 (CRC) 研究的潜力。

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LZ9

LZ9 Chemical Structure

CAS No. : 844441-29-8

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LZ9 相关抗体

Top Publications Citing Use of Products

查看 CDK 亚型特异性产品:

查看所有亚型
CDK1 CDK2 CDK3 CDK4 CDK5 CDK6 CDK7 CDK8 CDK9 CDK11 CDK12 CDK13 CDK14 CDK16 CDK19 CDC CLK Pho85 CDK10 CDK15 CDK17 CDK18 CDK20 PITSLRE

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

LZ9 is a ATP-competitive CDK1 and CDK2 inhibitor. LZ9 has the potential for the research of colorectal cancer (CRC)[1][2].

IC50 & Target[1]

CDK1

 

cyclin B1/CDC2

 

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
A-375 IC50
13.38 μM
Compound: 1
Antiproliferative activity against human A375 cells assessed as inhibition of cell growth incubated for 72 hrs by CCK-8 assay
Antiproliferative activity against human A375 cells assessed as inhibition of cell growth incubated for 72 hrs by CCK-8 assay
[PMID: 31991336]
A2058 IC50
1.011 μM
Compound: DC-K2in2
Antiproliferative activity against human A2058 cells assessed as reduction in cell viability measured after 96 hrs by Celltiter-Glo luminescent assay
Antiproliferative activity against human A2058 cells assessed as reduction in cell viability measured after 96 hrs by Celltiter-Glo luminescent assay
[PMID: 33611192]
HCT-116 IC50
1.4 μM
Compound: 23
Antiproliferative activity against human HCT116 cells assessed as cell viability after 72 hrs by alamar blue assay
Antiproliferative activity against human HCT116 cells assessed as cell viability after 72 hrs by alamar blue assay
[PMID: 18656911]
HCT-116 IC50
1.4 μM
Compound: 8d
Cytotoxicity against human HCT116 cells assessed as growth inhibition after 72 hrs by Alamar blue assay
Cytotoxicity against human HCT116 cells assessed as growth inhibition after 72 hrs by Alamar blue assay
[PMID: 26115571]
HCT-116 IC50
1.96 μM
Compound: 1
Antiproliferative activity against human HCT116 cells assessed as inhibition of cell growth incubated for 72 hrs by CCK-8 assay
Antiproliferative activity against human HCT116 cells assessed as inhibition of cell growth incubated for 72 hrs by CCK-8 assay
[PMID: 31991336]
HeLa IC50
8.23 μM
Compound: 1
Antiproliferative activity against human Hela cells assessed as inhibition of cell growth incubated for 72 hrs by CCK-8 assay
Antiproliferative activity against human Hela cells assessed as inhibition of cell growth incubated for 72 hrs by CCK-8 assay
[PMID: 31991336]
NCI-H460 IC50
9.46 μM
Compound: 1
Antiproliferative activity against human H460 cells assessed as inhibition of cell growth incubated for 72 hrs by CCK-8 assay
Antiproliferative activity against human H460 cells assessed as inhibition of cell growth incubated for 72 hrs by CCK-8 assay
[PMID: 31991336]
SMMC-7721 IC50
23.21 μM
Compound: 1
Antiproliferative activity against human SMMC7721 cells assessed as inhibition of cell growth incubated for 72 hrs by CCK-8 assay
Antiproliferative activity against human SMMC7721 cells assessed as inhibition of cell growth incubated for 72 hrs by CCK-8 assay
[PMID: 31991336]
分子量

360.29

Formula

C17H11F3N4O2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

LZ9 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

LZ9844441-29-8LZ 9LZ-9CDKCyclin dependent kinaseATP-competitivecolorectal cancerInhibitorinhibitorinhibit

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HY-170306
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