2. Academic Validation
  3. In vitro inducible nitric oxide synthesis inhibitory active constituents from Fraxinus rhynchophylla

In vitro inducible nitric oxide synthesis inhibitory active constituents from Fraxinus rhynchophylla

  • Planta Med. 1999 Oct;65(7):656-8. doi: 10.1055/s-2006-960840.
N Y Kim,  H O Pae,  Y S Ko,  J C Yoo,  B M Choi,  C D Jun,  H T Chung,  M Inagaki,  R Higuchi,  Y C Kim
PMID: 10575381 DOI: 10.1055/s-2006-960840
Abstract

Bioassay-guided fractionation of an H2O extract of the barks of Fraxinus rhynchophylla has furnished two inducible nitric oxide synthase (iNOS) inhibitory compounds, ferulaldehyde (1) and scopoletin (3) together with a coumarin, fraxidin (2). Compounds 1 and 3 showed inhibition of nitric oxide (NO) synthesis in a dose-dependent manner by murine macrophage-like RAW 264.7 cells stimulated with interferon-gamma (IFN-gamma) plus lipopolysaccharide (LPS). The inhibition of NO synthesis of 1 was reflected in the decreased amount of iNOS protein, as determined by Western blotting.

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