2. Academic Validation
  3. Biaryl amide glucagon receptor antagonists

Biaryl amide glucagon receptor antagonists

  • Bioorg Med Chem Lett. 2004 May 3;14(9):2047-50. doi: 10.1016/j.bmcl.2004.02.056.
Ravi Kurukulasuriya 1,  Bryan K Sorensen,  James T Link,  Jyoti R Patel,  Hwan-Soo Jae,  Marty X Winn,  Jeffrey R Rohde,  Nelson D Grihalde,  Chun W Lin,  Christopher A Ogiela,  Andrew L Adler,  Christine A Collins
Affiliations

Affiliation

  • 1 Metabolic Disease Research, Global Pharmaceutical Research and Development, Abbott Laboratories, 100 Abbott Park Road, Abbott Park, IL 60064-6098, USA. ravi.kurukulasuriya@abbott.com
PMID: 15080976 DOI: 10.1016/j.bmcl.2004.02.056
Abstract

Biaryl amides derived from a reported series of ureas 1 were evaluated and found to be potent human Glucagon Receptor antagonists. The benzofuran analogue 6i was administered in Sprague-Dawley rats and blocked the effects of an exogenous glucagon challenge.

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