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  3. Epoetin zeta in the management of anemia associated with chronic kidney disease, differential pharmacology and clinical utility

Epoetin zeta in the management of anemia associated with chronic kidney disease, differential pharmacology and clinical utility

  • Biologics. 2014 Apr 16;8:155-67. doi: 10.2147/BTT.S27578.
Mary Lynn Davis-Ajami 1,  Jun Wu 2,  Katherine Downton 3,  Emilie Ludeman 3,  Virginia Noxon 4
Affiliations

Affiliations

  • 1 Organizational Systems and Adult Health, University of Maryland School of Nursing, Baltimore, MD, USA.
  • 2 South Carolina College of Pharmacy, University of South Carolina, Greenville, SC, USA.
  • 3 Health Sciences and Human Services Library, University of Maryland, Baltimore, MD, USA.
  • 4 Department of Clinical Pharmacy and Outcomes Science, South Carolina College of Pharmacy, University of South Carolina, Columbia, SC, USA.
PMID: 24790409 DOI: 10.2147/BTT.S27578
Abstract

Epoetin zeta was granted marketing authorization in October 2007 by the European Medicines Agency as a recombinant human erythropoietin erythropoiesis-stimulating agent to treat symptomatic anemia of renal origin in adult and pediatric patients on hemodialysis and adults on peritoneal dialysis, as well as for symptomatic renal anemia in adult patients with renal insufficiency not yet on dialysis. Currently, epoetin zeta can be administered either subcutaneously or intravenously to correct for hemoglobin concentrations ≤10 g/dL (6.2 mmol/L) or with dose adjustment to maintain hemoglobin levels at desired levels not in excess of 12 g/dL (7.5 mmol/L). This review article focuses on epoetin zeta indications in chronic kidney disease, its use in managing anemia of renal origin, and discusses its pharmacology and clinical utility.

Keywords

Retacrit®; biosimilar; chronic kidney disease; epoetin alfa; erythropoiesis; renal anemia.

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