2. Academic Validation
  3. Chemical components of Ardisia splendens leaves and their activity against coxsackie A16 viruses

Chemical components of Ardisia splendens leaves and their activity against coxsackie A16 viruses

  • Nat Prod Commun. 2014 May;9(5):643-5.
Thi Hong Van Nguyen,  Trinh Anh Vien,  Nguyen Xuan Nhiem,  Phan Van Kiem,  Chau Van Minh,  Pham Quoc Long,  Luu Tuan Anh,  Nguyen Manh Cuong,  Jae-Hyoung Song,  Hyun-Jeong Ko,  Nanyoung Kim,  Seon Ju Park,  Seung Hyun Kim
PMID: 25026709
Abstract

Using a combination of chromatographic methods, one new flavonol glycoside, myricetin 3,7-di-O-alpha-L-rhamnopyranoside (1), and nine known compounds myricitrin (2), quercetin 3,7-di-O-alpha-L-rhamnopyranoside (3), quercitrin (4), desmanthin-l (5), myricetin 3-O-(3"-O-galloyl)-alpha-L-rhamnopyranoside (6), (+)-catechin (7), benzyl O-1-D-glucopyranoside (8), 2-phenylethyl O-beta-D-glucopyranoside (9), and corilagin (10) were isolated from the leaves of Ardisia splendens Pit. Based on an in vitro test against Coxsackie viruses A16 by SRB assay, only compounds 2, 5, and 10 exhibited activity against Coxsackie viruses A16 with IC50 values of 40.1, 32.2, and 30.5 microM, respectively. This result suggested that compounds 2, 5, and 10 might be potential agents for treating hand, foot and mouth diseases.

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