2. Academic Validation
  3. Low-oxygen response is triggered by an ATP-dependent shift in oleoyl-CoA in Arabidopsis

Low-oxygen response is triggered by an ATP-dependent shift in oleoyl-CoA in Arabidopsis

  • Proc Natl Acad Sci U S A. 2018 Dec 18;115(51):E12101-E12110. doi: 10.1073/pnas.1809429115.
Romy R Schmidt 1,  Martin Fulda 2,  Melanie V Paul 3,  Max Anders 4,  Frederic Plum 4,  Daniel A Weits 4,  Monika Kosmacz 5,  Tony R Larson 6,  Ian A Graham 6,  Gerrit T S Beemster 7,  Francesco Licausi 8 9,  Peter Geigenberger 3,  Jos H Schippers 4,  Joost T van Dongen 1
Affiliations

Affiliations

  • 1 Institute of Biology I, Rheinisch-Westfälische Technische Hochschule Aachen University, 52074 Aachen, Germany; roschmidt@bio1.rwth-aachen.de dongen@bio1.rwth-aachen.de.
  • 2 Albrecht von Haller Institute of Plant Sciences, Goettingen University, 37077 Goettingen, Germany.
  • 3 Department Biology I, Ludwig Maximilian University of Munich, 82152 Planegg-Martinsried, Germany.
  • 4 Institute of Biology I, Rheinisch-Westfälische Technische Hochschule Aachen University, 52074 Aachen, Germany.
  • 5 Max Planck Institute of Molecular Plant Physiology, 14476 Potsdam, Germany.
  • 6 Department of Biology, University of York, Heslington, YO10 5DD York, United Kingdom.
  • 7 Integrated Molecular Plant Physiology Research Group, University of Antwerp, G.U.613, 2020 Antwerpen, Belgium.
  • 8 PlantLab, Institute of Life Sciences, Scuola Superiore Sant'Anna, 56017 Pisa, Italy.
  • 9 Dipartimento di Biologia,Università di Pisa, 56126 Pisa, Italy.
PMID: 30509981 DOI: 10.1073/pnas.1809429115
Abstract

Plant response to environmental stimuli involves integration of multiple signals. Upon low-oxygen stress, Plants initiate a set of adaptive responses to circumvent an energy crisis. Here, we reveal how these stress responses are induced by combining (i) energy-dependent changes in the composition of the acyl-CoA pool and (ii) the cellular oxygen concentration. A hypoxia-induced decline of cellular ATP levels reduces LONG-CHAIN ACYL-COA SYNTHETASE activity, which leads to a shift in the composition of the acyl-CoA pool. Subsequently, we show that different acyl-CoAs induce unique molecular responses. Altogether, our data disclose a role for acyl-CoAs acting in a cellular signaling pathway in Plants. Upon hypoxia, high oleoyl-CoA levels provide the initial trigger to release the transcription factor RAP2.12 from its interaction partner ACYL-COA BINDING PROTEIN at the plasma membrane. Subsequently, according to the N-end rule for proteasomal degradation, oxygen concentration-dependent stabilization of the subgroup VII ETHYLENE-RESPONSE FACTOR transcription factor RAP2.12 determines the level of hypoxia-specific gene expression. This research unveils a specific mechanism activating low-oxygen stress responses only when a decrease in the oxygen concentration coincides with a drop in energy.

Keywords

ACBP; ERFVII; acyl-CoA; integrative signaling; low-oxygen stress.

Figures
Products
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z