2. Academic Validation
  3. Possible molecular mechanisms of glucose-lowering activities of Momordica charantia (karela) in diabetes

Possible molecular mechanisms of glucose-lowering activities of Momordica charantia (karela) in diabetes

  • J Cell Biochem. 2019 Jul;120(7):10921-10929. doi: 10.1002/jcb.28483.
Naseh Pahlavani 1 2,  Fatemeh Roudi 1 2,  Mohsen Zakerian 3,  Gordon A Ferns 4,  Jamshid Gholizadeh Navashenaq 5,  Amir Mashkouri 6,  Majid Ghayour-Mobarhan 2 7,  Hamidreza Rahimi 8 9
Affiliations

Affiliations

  • 1 Students Research Committee, Mashhad University of Medical Sciences, Mashhad, Iran.
  • 2 Department of Nutrition, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
  • 3 Department of Persian Medicine, School of Persian and Complementary Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
  • 4 Brighton & Sussex Medical School, Division of Medical Education, Brighton, Sussex, UK.
  • 5 Immunology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
  • 6 Students Research Committee, Imam Reza International University, Mashhad, Iran.
  • 7 Cardiovascular Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
  • 8 Department of Modern Sciences and Technology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
  • 9 Neurogenic Inflammation Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
PMID: 30790347 DOI: 10.1002/jcb.28483
Abstract

Diabetes mellitus is a highly prevalent metabolic disorder which is characterized by impaired glucose tolerance, with a relative or absolute Insulin deficiency and profound changes in the metabolism of macronutrients. Traditional and complementary medicine is therapeutic strategies that have both been applied to improving glycemic control. Momordica charantia is one of the plant-based, folk medicines that used for improving glycemic control. We aimed to review, the effects of M. charantia on blood glucose with a clarification of the molecular pathways involved. Of the compounds derived from the Plants, the insulin-like peptide, charantin, and the alkaloid vicine, have been reported to have hypoglycemic effects. Different mechanisms contribute to the antidiabetic activities of M. charantia, these include increasing pancreatic Insulin secretion, decreasing Insulin resistance and increasing peripheral and skeletal muscle cell glucose utilization, inhibition of intestinal glucose absorption and suppressing of key enzymes in the gluconeogenic pathways.

Keywords

Momordica charantia; diabetes; glycemic indices; molecular mechanisms.

Figures
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z