2. Academic Validation
  3. Glucagon Regulation of Energy Expenditure

Glucagon Regulation of Energy Expenditure

  • Int J Mol Sci. 2019 Oct 30;20(21):5407. doi: 10.3390/ijms20215407.
Maximilian Kleinert 1 2,  Stephan Sachs 3 4,  Kirk M Habegger 5,  Susanna M Hofmann 6 7 8,  Timo D Müller 9 10 11
Affiliations

Affiliations

  • 1 Institute for Diabetes and Obesity, Helmholtz Diabetes Center at Helmholtz Centre Munich, Ingolstädter Landstraße 1, 85764 Oberschleißheim, Germany. maximilian.kleinert@helmholtz-muenchen.de.
  • 2 Section of Molecular Physiology, Department of Nutrition, Exercise and Sports, University of Copenhagen, 2100 Copenhagen, Denmark. maximilian.kleinert@helmholtz-muenchen.de.
  • 3 Institute for Diabetes and Obesity, Helmholtz Diabetes Center at Helmholtz Centre Munich, Ingolstädter Landstraße 1, 85764 Oberschleißheim, Germany. stephan.sachs@helmholtz-muenchen.de.
  • 4 Division of Metabolic Diseases, Technische Universität München, 85740 Munich, Germany. stephan.sachs@helmholtz-muenchen.de.
  • 5 Department of Medicine-Endocrinology and Comprehensive Diabetes Center, Diabetes and Metabolism, University of Alabama at Birmingham, Birmingham, AL 35899, USA. kirkhabegger@uabmc.edu.
  • 6 Institute for Diabetes and Regeneration, Helmholtz Diabetes Center at Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), 85764 Neuherberg, Germany. usanna.hofmann@helmholtz-muenchen.de.
  • 7 German Center for Diabetes Research (DZD), 85764 Neuherberg, Germany. usanna.hofmann@helmholtz-muenchen.de.
  • 8 Medizinische Klinik und Poliklinik IV, Klinikum der LMU, 80336 München, Germany. usanna.hofmann@helmholtz-muenchen.de.
  • 9 Institute for Diabetes and Obesity, Helmholtz Diabetes Center at Helmholtz Centre Munich, Ingolstädter Landstraße 1, 85764 Oberschleißheim, Germany. timo.mueller@helmholtz-muenchen.de.
  • 10 German Center for Diabetes Research (DZD), 85764 Neuherberg, Germany. timo.mueller@helmholtz-muenchen.de.
  • 11 Department of Pharmacology and Experimental Therapy, Institute of Experimental and Clinical Pharmacology and Toxicology, Eberhard Karls University Hospitals and Clinics, 72076 Tübingen, Germany. timo.mueller@helmholtz-muenchen.de.
PMID: 31671603 DOI: 10.3390/ijms20215407
Abstract

Glucagon's ability to increase energy expenditure has been known for more than 60 years, yet the mechanisms underlining glucagon's thermogenic effect still remain largely elusive. Over the last years, significant efforts were directed to unravel the physiological and cellular underpinnings of how glucagon regulates energy expenditure. In this review, we summarize the current knowledge on how glucagon regulates systems metabolism with a special emphasis on its acute and chronic thermogenic effects.

Keywords

FGF21; brown adipose tissue; energy expenditure; glucagon; obesity; pharmacology.

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