1. Academic Validation
  2. Procalcitonin: Where Are We Now?

Procalcitonin: Where Are We Now?

  • Crit Care Clin. 2020 Jan;36(1):23-40. doi: 10.1016/j.ccc.2019.08.003.
Bachar Hamade 1 David T Huang 2
Affiliations

Affiliations

  • 1 Department of Emergency Medicine, American University of Beirut Medical Center, 2nd Floor, Cairo Street, Beirut, Lebanon; Department of Critical Care Medicine, University of Pittsburgh Medical Center, 3550 Terrace Street, Room 651, Scaife Hall, Pittsburgh, PA 15261, USA.
  • 2 Departments of Critical Care Medicine and Emergency Medicine, The MACRO (Multidisciplinary Acute Care Research Organization) and CRISMA (Clinical Research, Investigation, and Systems Modeling of Acute illness) Centers, University of Pittsburgh, 3550 Terrace Street, Room 606B, Scaife Hall, Pittsburgh, PA 15261, USA. Electronic address: huangdt@upmc.edu.
Abstract

Procalcitonin is a biomarker that is generally elevated in Bacterial infections. This review describes a conceptual framework for biomarkers using lessons from the history of troponin, applies this framework to procalcitonin with a review of observational studies and randomized trials in and out of the intensive care unit, and concludes with clinical recommendations and thoughts on how to test a test.

Keywords

Antibiotics; Mortality; Procalcitonin; Respiratory tract infection; Sepsis.

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