2. Academic Validation
  3. Identification of SARS-CoV-2-specific immune alterations in acutely ill patients

Identification of SARS-CoV-2-specific immune alterations in acutely ill patients

  • J Clin Invest. 2021 Apr 15;131(8):e145853. doi: 10.1172/JCI145853.
Rose-Marie Rébillard 1 2,  Marc Charabati 1 2,  Camille Grasmuck 1 2,  Abdelali Filali-Mouhim 2,  Olivier Tastet 2,  Nathalie Brassard 2,  Audrey Daigneault 2,  Lyne Bourbonnière 2,  Sai Priya Anand 2 3,  Renaud Balthazard 1 2,  Guillaume Beaudoin-Bussières 2 4,  Romain Gasser 2 4,  Mehdi Benlarbi 2 4,  Ana Carmena Moratalla 1 2,  Yves Carpentier Solorio 1 2,  Marianne Boutin 2 4,  Negar Farzam-Kia 1 2,  Jade Descôteaux-Dinelle 2 4,  Antoine Philippe Fournier 1 2,  Elizabeth Gowing 1 2,  Annemarie Laumaea 2 4,  Hélène Jamann 1 2,  Boaz Lahav 2,  Guillaume Goyette 2,  Florent Lemaître 1 2,  Victoria Hannah Mamane 1 2,  Jérémie Prévost 2 4,  Jonathan Richard 2 4,  Karine Thai 1 2,  Jean-François Cailhier 2 5,  Nicolas Chomont 2 4,  Andrés Finzi 2 3 4,  Michaël Chassé 2 5,  Madeleine Durand 2 5,  Nathalie Arbour 1 2,  Daniel E Kaufmann 2 5,  Alexandre Prat 1 2,  Catherine Larochelle 1 2
Affiliations

Affiliations

  • 1 Department of Neuroscience, Université de Montréal, Montreal, Quebec, Canada.
  • 2 Centre de recherche du Centre hospitalier de l'Université de Montréal (CRCHUM), Montreal, Quebec, Canada.
  • 3 Department of Microbiology and Immunology, McGill University, Montreal, Quebec, Canada.
  • 4 Department of Microbiology, Infectious Diseases and Immunology, and.
  • 5 Department of Medicine, Université de Montréal, Montreal, Quebec, Canada.
PMID: 33635833 DOI: 10.1172/JCI145853
Abstract

Dysregulated immune profiles have been described in symptomatic patients infected with SARS-CoV-2. Whether the reported immune alterations are specific to SARS-CoV-2 Infection or also triggered by other acute illnesses remains unclear. We performed flow cytometry analysis on fresh peripheral blood from a consecutive cohort of (a) patients hospitalized with acute SARS-CoV-2 Infection, (b) patients of comparable age and sex hospitalized for another acute disease (SARS-CoV-2 negative), and (c) healthy controls. Using both data-driven and hypothesis-driven analyses, we found several dysregulations in immune cell subsets (e.g., decreased proportion of T cells) that were similarly associated with acute SARS-CoV-2 Infection and non-COVID-19-related acute illnesses. In contrast, we identified specific differences in myeloid and lymphocyte subsets that were associated with SARS-CoV-2 status (e.g., elevated proportion of ICAM-1+ mature/activated neutrophils, ALCAM+ monocytes, and CD38+CD8+ T cells). A subset of SARS-CoV-2-specific immune alterations correlated with disease severity, disease outcome at 30 days, and mortality. Our data provide an understanding of the immune dysregulation specifically associated with SARS-CoV-2 Infection among acute care hospitalized patients. Our study lays the foundation for the development of specific biomarkers to stratify SARS-CoV-2-positive patients at risk of unfavorable outcomes and to uncover candidate molecules to investigate from a therapeutic perspective.

Keywords

Adaptive immunity; COVID-19; Innate immunity.

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