2. Academic Validation
  3. GNA13 inhibits glioblastoma metastasis via the ERKs/FOXO3 signaling pathway

GNA13 inhibits glioblastoma metastasis via the ERKs/FOXO3 signaling pathway

  • Cell Signal. 2023 Jun 29;110789. doi: 10.1016/j.cellsig.2023.110789.
Qingfeng Yi 1,  Meihui Huang 2,  Xiaona Zhang 2,  Zhennan Xu 3,  Jianhong Sun 4,  Shaohong Wang 4,  Haixiong Xu 5,  Zepeng Du 6,  Mingfa Liu 7
Affiliations

Affiliations

  • 1 Clinical Research Center, Shantou Central Hospital, Shantou 515031, Guangdong, China; Department of Neurosurgery, Shantou Central Hospital, Shantou 515031, Guangdong, China.
  • 2 Department of Central Laboratory, Shantou Central Hospital, Shantou 515031, Guangdong, China.
  • 3 Department of Neurosurgery, Shantou Central Hospital, Shantou 515031, Guangdong, China.
  • 4 Department of Pathology, Shantou Central Hospital, Shantou 515031, Guangdong, China.
  • 5 Department of Neurosurgery, Shantou Central Hospital, Shantou 515031, Guangdong, China; Shantou Academy of Medical Sciences, Shantou 515031, Guangdong, China. Electronic address: xuhaix@126.com.
  • 6 Department of Central Laboratory, Shantou Central Hospital, Shantou 515031, Guangdong, China; Department of Pathology, Shantou Central Hospital, Shantou 515031, Guangdong, China. Electronic address: zepdu@126.com.
  • 7 Department of Neurosurgery, Shantou Central Hospital, Shantou 515031, Guangdong, China. Electronic address: stlmf1163@sina.com.
PMID: 37392861 DOI: 10.1016/j.cellsig.2023.110789
Abstract

Glioblastoma (GBM) is a malignant tumor characterized by poor prognosis and low overall survival (OS) rate. Identification of novel biological markers for the diagnosis and treatment of GBM is crucial to developing interventions to improve patient survival. GNA13, a member of the G12 family, has been reported to play important roles in a variety of biological processes involved in tumorigenesis and development. However, its role in GBM is currently unknown. Here, we explored the expression patterns and functions of GNA13 in GBM, as wells its impact on metastasis process. Results showed that GNA13 was downregulated in GBM tissues and correlated with poor prognosis of GBM. Downregulation of GNA13 promoted the migration, invasion and proliferation of GBM cells; whereas its overexpression abolished these effects. Western blots revealed that GNA13 knockdown and overexpression upregulated and inhibited the phosphorylation of ERKs, respectively. Moreover, GNA13 was the upstream of ERKs signaling to regulating ERKs phosphorylation level. Furthermore, U0126 alleviated the metastasis effect induced by GNA13 knockdown. Bioinformatics analyses and qRT-PCR experiments demonstrated that GNA13 could regulate FOXO3, a downstream signaling molecule of ERKs pathway. Overall, our results demonstrate that GNA13 expression is negatively correlated with GBM and can suppress tumor metastasis by inhibiting the ERKs signaling pathway and upregulating FOXO3 expression.

Keywords

ERKs/ FOXO3 pathway; GBM; GNA13; Metastasis.

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