2. Academic Validation
  3. Antimicrobial activity of 4-hydroxybenzoic acid and trans 4-hydroxycinnamic acid isolated and identified from rice hull

Antimicrobial activity of 4-hydroxybenzoic acid and trans 4-hydroxycinnamic acid isolated and identified from rice hull

  • Biosci Biotechnol Biochem. 1998 Nov;62(11):2273-6. doi: 10.1271/bbb.62.2273.
J Y Cho 1,  J H Moon,  K Y Seong,  K H Park
Affiliations

Affiliation

  • 1 Department of Food Science and Technology, Chonnam National University, Kwangju, Korea.
PMID: 9972252 DOI: 10.1271/bbb.62.2273
Abstract

Two antimicrobial substances in rice hull were isolated and identified as 4-hydroxybenzoic acid and trans 4-hydroxycinnamic acid by LC-MS, and 1H- and 13C-NMR. An evaluation of 50% inhibition of growth (IC50) revealed that the two substances had different inhibition profiles against various Microorganisms. Most of the gram-positive and some gram-negative bacteria were sensitive to trans 4-hydroxycinnamic acid and 4-hydroxybenzoic acid at IC50 concentrations of 100-170 and 160 micrograms/ml, respectively.

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