2. Neuronal Signaling
  3. Cholinesterase (ChE) Beta-secretase Amyloid-β
  4. Memoquin

Memoquin 是一种抗淀粉样蛋白和抗氧化的多靶点配体。Memoquin 是具有口服活性的 BACE-1 和 AChE 抑制剂，IC50 值分别为 108 和 1.55 nM。Memoquin 是一种认知增强剂，可预防氧化应激介导的 Aβ 诱导的神经毒性。Memoquin 可用于阿尔茨海默病的研究。

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Memoquin Chemical Structure

Memoquin Chemical Structure

CAS No. : 616885-87-1

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Memoquin 相关抗体

Top Publications Citing Use of Products

查看 Cholinesterase (ChE) 亚型特异性产品:

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AChE BChE

查看 Beta-secretase 亚型特异性产品:

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BACE1 BACE2

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Memoquin is an anti-amyloid and anti-oxidant multi-target-directed ligand. Memoquin is an orally active inhibitor of BACE-1 and AChE with IC50 values of 108 and 1.55 nM, respectively. Memoquin is a cognitive enhancer that prevents the Aβ-induced neurotoxicity mediated by oxidative stress. Memoquin can be used for the research of Alzheimer’s disease (AD)[1][2].

IC50 & Target

hAChE

1.55 nM (IC50)

BACE1

108 nM (IC50)

体外研究
(In Vitro)

Memoquin 抑制 hAChE，hAChE 诱导的 Aβ(1-40) 聚集，Aβ(1-42) 自聚集和 BACE-1 的 IC50 值分别为 0.00155，28.3，5.93 和 0.108 μM[2]。
Memoquin 具有与 hAChE 结合的特性，Ki 值为 2.6 nM[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Memoquin 相关抗体:
体内研究
(In Vivo)

Memoquin (7-15 mg/kg；口服，一次) 可挽救 scopolamine 诱导的遗忘模型的记忆缺陷[1]。
Memoquin (15 mg/kg；口服，每天 1 次，连续 2-6 天) 6 天处理可完全挽救 Aβ1-42 诱导的遗忘模型的记忆缺陷[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Mice with scopolamine-induced amnesia[1]
Dosage: 7, 10 and 15 mg/kg
Administration: Oral administration; 7, 10 and 15 mg/kg, once
Result: Reversed the scopolamine-induced memory deficits and verified by a T-maze test. Rescueed episodic memory impairment at a dose of 15 mg/kg.
Animal Model: Mice with Aβ- induced amnesia[1]
Dosage: 15 mg/kg
Administration: Oral administration; 15 mg/kg, daily for 2, 4, and 6 days before behavioral testing
Result: Weekly alleviated the insult induced by Aβ1-42 for 2-4 days treatment and fully rescued with a 6-day treatment.
分子量

632.88

Formula

C38H56N4O4
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Memoquin 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Memoquin616885-87-1Cholinesterase (ChE)Beta-secretaseAmyloid-βBACEβ-Secretase β-amyloid peptideAβAbetaamyloidanti-oxidantmulti-targetcognitive enhancerAlzheimer’s diseasescopolamineInhibitorinhibitorinhibit

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