Methylprednisolone aceponate  (Synonyms: ZK 91588; MPA)

Methylprednisolone aceponate (ZK 91588) is a glucocorticoid and anti-inflammatory agent with weak systemic effects. Methylprednisolone aceponate is a selective glucocorticoid receptor Ligand.Methylprednisolone aceponate can be used for research of eczema and other inflammatory skin disorders^[1][2][3].

Methylprednisolone aceponate 抑制胶原酶启动子活性 (在 HeLa 细胞中)、LPS 诱导的 IL-12p40 分泌 (在人 PBMC 中) 和植物凝集素诱导的 IFN-γ 分泌 (在人 PBMC 中)，IC₅₀s 分别为 9.3 , 16.8, 15.2 nM^[3].
Methylprednisolone aceponate 激活 MMTV 启动子和 TAT 活性，EC₅₀ 分别为 21.8 和 20.5 nM^[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Methylprednisolone aceponate (局部应用, 50 μL, 巴豆油引起的伊文蓝水肿模型) 具有抗炎作用，IC₅₀ 为 0.0015%，全身副作用低^[1].
Methylprednisolone aceponate (0.0001%-0.1%，局部应用) 在小鼠和大鼠的刺激性接触性皮炎中抑制水肿形成，ED₅₀ 为 0.002%^[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

472.57

C₂₇H₃₆O₇

86401-95-8

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Ruzicka T. Methylprednisolone aceponate in eczema and other inflammatory skin disorders -- a clinical update. Int J Clin Pract. 2006 Jan;60(1):85-92.  [Content Brief]

  [2]. H.J. Zentel, et al. Preclinical evaluation of a new topical corticosteroid methylprednisolone aceponate. 1994. 3 (s1), S32-S38.

  [3]. Schäcke H, et al. Characterization of ZK 245186, a novel, selective glucocorticoid receptor agonist for the topical treatment of inflammatory skin diseases. Br J Pharmacol. 2009 Oct;158(4):1088-103.  [Content Brief]