2. Immunology/Inflammation
  3. Macrophage migration inhibitory factor (MIF)
  4. MIF2-IN-1

MIF2-IN-1 (compound 5d) 是一种有效的 MIF2 互变异构酶抑制剂，IC50 为 1.0 μM。MIF2-IN-1 通过 MAPK 通路诱导细胞周期停滞来抑制非小细胞肺癌细胞的增殖。MIF2-IN-1 具有研究癌症疾病的潜力。

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MIF2-IN-1

MIF2-IN-1 Chemical Structure

CAS No. : 2917525-79-0

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MIF2-IN-1 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

MIF2-IN-1 (compound 5d) is a potent inhibitor of MIF2 tautomerase with an IC50 of 1.0 μM. MIF2-IN-1 suppresses the proliferation of non-small cell lung cancer cells by the induction of cell cycle arrest via deactivation of the MAPK pathway. MIF2-IN-1 has the potential for the research of cancer diseases[1].

IC50 & Target

IC50: 1.0 μM (MIF2)[1]
细胞效力
(Cellular Effect)
Cell Line Type Value Description References
A549 IC50
3 μM
Compound: 5d
Antiproliferative against human A549 cells assessed as inhibition of cell viability measured after 72 hrs by fluorescence based assay
Antiproliferative against human A549 cells assessed as inhibition of cell viability measured after 72 hrs by fluorescence based assay
[PMID: 35041425]
HCC827 IC50
5.2 μM
Compound: 5d
Antiproliferative against human HCC827 cells assessed as inhibition of cell viability measured after 72 hrs by fluorescence based assay
Antiproliferative against human HCC827 cells assessed as inhibition of cell viability measured after 72 hrs by fluorescence based assay
[PMID: 35041425]
NCI-H1299 IC50
7.6 μM
Compound: 5d
Antiproliferative against human NCI-H1299 cells assessed as inhibition of cell viability measured after 72 hrs by fluorescence based assay
Antiproliferative against human NCI-H1299 cells assessed as inhibition of cell viability measured after 72 hrs by fluorescence based assay
[PMID: 35041425]
NCI-H1650 IC50
5.3 μM
Compound: 5d
Antiproliferative against human NCI-H1650 cells assessed as inhibition of cell viability measured after 72 hrs by fluorescence based assay
Antiproliferative against human NCI-H1650 cells assessed as inhibition of cell viability measured after 72 hrs by fluorescence based assay
[PMID: 35041425]
分子量

480.50

Formula

C26H19F3N2O2S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

MIF2-IN-1 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MIF2-IN-12917525-79-0Macrophage migration inhibitory factor (MIF)MIF2proliferationcell cycle arrestMAPKcancerInhibitorinhibitorinhibit

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目录号：
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