1. Protein Tyrosine Kinase/RTK
    PROTAC
  2. Btk
    Ligand for Target Protein for PROTAC
  3. N-piperidine Ibrutinib hydrochloride

N-piperidine Ibrutinib hydrochloride 

目录号: HY-130983
产品使用指南

N-piperidine Ibrutinib hydrochloride (Compound 1) 是一种可逆的 Ibrutinib 衍生物,N-piperidine Ibrutinib hydrochloride 是一种有效的 BTK 抑制剂,对 WT BTK 和 C481S BTK 的 IC50 值分别为 51.0 和 30.7 nM。N-piperidine Ibrutinib hydrochloride 可作为 BTK 配体,用于合成一系列 PROTAC 分子,如 SJF620 (HY-133137)。SJF620 是一种 PROTAC BTK 降解剂,DC50 为 7.9 nM。

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N-piperidine Ibrutinib hydrochloride Chemical Structure

N-piperidine Ibrutinib hydrochloride Chemical Structure

CAS No. : 2231747-18-3

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Description

N-piperidine Ibrutinib hydrochloride (Compound 1) is a reversible Ibrutinib derivative. N-piperidine Ibrutinib hydrochloride is a potent BTK inhibitor with IC50s of 51.0 and 30.7 nM for WT BTK and C481S BTK, respectively[1]. N-piperidine Ibrutinib hydrochloride can be used as a BTK ligand in the synthesis of a series of PROTACs, such as SJF620 (HY-133137). SJF620 is a potent PROTAC BTK degrader with a DC50 of 7.9 nM[2].

IC50 & Target

IC50: 51.0 nM (WT BTK), 30.7 nM (C481S BTK)[1]

In Vitro

N-piperidine Ibrutinib hydrochloride can be used as a BTK ligand in the synthesis of a series of PROTACs. SJF638, SJF678, and SJF608 are potent PROTAC BTK degraders with DC50s of 374, 162, and 8.3 nM, respectively[2].

Molecular Weight

422.91

Formula

C₂₂H₂₃ClN₆O

CAS No.

2231747-18-3

SMILES

NC1=C2C(N(C3CCNCC3)N=C2C4=CC=C(OC5=CC=CC=C5)C=C4)=NC=N1.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

N-piperidine IbrutinibBtkLigand for Target Protein for PROTACBruton tyrosine kinaseTarget Protein-binding MoietyreversibleC481SPROTACsdegraderInhibitorinhibitorinhibit

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产品名称:
N-piperidine Ibrutinib hydrochloride
目录号:
HY-130983
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