1. PROTAC
    Protein Tyrosine Kinase/RTK
  2. PROTAC
    Btk
  3. SJF620

SJF620 

目录号: HY-133137
产品使用指南

SJF620 是一种 PROTAC BTK 降解剂,DC50 为 7.9 nM。SJF620 含有 Lenalidomide 类似物,可募集 CRBN。

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SJF620 Chemical Structure

SJF620 Chemical Structure

CAS No. : 2376187-16-3

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Size Price Stock
5 mg ¥5800 Ask For Quote & Lead Time
10 mg ¥9800 Ask For Quote & Lead Time
25 mg ¥19000 Ask For Quote & Lead Time

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Description

SJF620 is a potent PROTAC BTK degrader with a DC50 of 7.9 nM. SJF620 contains a Lenalidomide analog for recruiting CRBN[1].

IC50 & Target[1]

Cereblon

 

In Vitro

SJF620 is a PROTAC that retains potent degradation of BTK in cellular assays with a DC50 of 7.9 nM in Burkitt lymphoma cell line NAMALWA[1].

In Vivo

SJF620 has a super pharmacokinetic profile in mice (1 mg/kg; i.v.) with half life (t1/2) of 1.64 h. SJF620 exhibits a significantly better pharmacokinetic profile than MT802[1].

Molecular Weight

760.84

Formula

C₄₁H₄₄N₈O₇

CAS No.

2376187-16-3

SMILES

O=C(C(N(CC1=C2C=CC(OCCOCCOCCN3CCC(N4N=C(C5=CC=C(OC6=CC=CC=C6)C=C5)C7=C(N)N=CN=C74)CC3)=C1)C2=O)CC8)NC8=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

SJF620SJF 620SJF-620PROTACBtkProteolysis-targeting chimeraBruton tyrosine kinaseInhibitorinhibitorinhibit

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产品名称:
SJF620
目录号:
HY-133137
需求量: