2. Membrane Transporter/Ion Channel
  3. Sodium Channel
  4. NaV1.2/1.6 channel blocker-1

NaV1.2/1.6 channel blocker-1 是一种有效的 NaV1.2/1.6 channel 阻滞剂，抑制 rNaV1.6 和 hNaV1.2 的 IC50 值分别为 9.8 和 24.4 μM。NaV1.2/1.6 channel blocker-1 可用于全身性癫痫的研究。

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NaV1.2/1.6 channel blocker-1 Chemical Structure

NaV1.2/1.6 channel blocker-1 Chemical Structure

CAS No. : 1199944-04-1

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NaV1.2/1.6 channel blocker-1 相关抗体

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  • 生物活性

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  • 参考文献

生物活性

NaV1.2/1.6 channel blocker-1 is a potent NaV1.2/1.6 channel blocker, with IC50s of 9.8 and 24.4 μM for rNaV1.6 and hNaV1.2, respectively. NaV1.2/1.6 channel blocker-1 can be used for the research of generalized epilepsy[1].

IC50 & Target[1]

rNaV1.6

9.8 μM (IC50)

hNaV1.2

24.4 μM (IC50)

体外研究
(In Vitro)

NaV1.2/1.6 channel blocker-1 (compound 13) (1-100 μM) 在稳定表达大鼠 NaV1.6 和人 NaV1.2 同种型的 HEK 293 细胞中分别阻断 48.5% 和 34.0% 的 NaV1.6 和 NaV1.2 钠电流[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

NaV1.2/1.6 channel blocker-1 相关抗体:
分子量

258.34

Formula

C14H14N2OS
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

NaV1.2/1.6 channel blocker-1 相关分类

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  • Do most proteins show cross-species activity?

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Keywords:

NaV1.2/1.6 channel blocker-11199944-04-1Sodium ChannelNa channelsNa+ channelsrNaV1.6hNaV1.2generalized epilepsyInhibitorinhibitorinhibit

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