2. Immunology/Inflammation
  3. NOD-like Receptor (NLR)
  4. NDT-19795

NDT-19795 是一种有效的 NLRP3 炎性体 抑制剂，在 PBMC 方法中的 IC50 值为 66 nM, 在WB 方法中的 IC50 值为 4.7 μM。NDT-19795 是羧酸活性物质，可在细胞内由 NT-0796 (HY-156438) 转化而成。NDT-19795 可以用于神经性疾病的研究。

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NDT-19795 Chemical Structure

NDT-19795 Chemical Structure

CAS No. : 2272917-12-9

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NDT-19795 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

NDT-19795 is an effective inhibitor of the NLRP3 inflammasome with an IC50 value of 66 nM in the PBMC method and 4.7 μM in the WB method. NDT-19795 is a carboxylic acid-active substance that can be converted from NT-0796 (HY-156438) within cells. NDT-19795 can be used for the study of neurological diseases[1].

IC50 & Target

IC50: 66 nM (NLRP3 inflammasome, PBMC)[1].
IC50: 4.7 μM (NLRP3 inflammasome; WB)[1].
体内研究
(In Vivo)

NDT-19795 (3 mg/kg; 静脉注射; 单剂量) 在 C57BL/6 小鼠中的脑血比为 0.07 ，血脑屏障透过性较低[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

367.40

Formula

C20H21N3O4
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

NDT-19795 相关分类

  • 摩尔计算器

  • 稀释计算器

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

NDT-197952272917-12-9NDT19795NDT 19795NOD-like Receptor (NLR)C57BL/6NT-079neurological diseasesInhibitorinhibitorinhibit

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NDT-19795
目录号：
HY-158024
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