2. Apoptosis
  3. Apoptosis
  4. Neihulizumab

Neihulizumab  (Synonyms: ALTB-168; Anti-PSGL1/CD162 Reference Antibody (neihulizumab))

目录号: HY-P99378 纯度: 98.10%
COA

摩尔计算器

Neihulizumab (ALTB-168) 是一种免疫检查点激动性抗体，可与人 CD162 (PSGL-1)结合，导致活化的 T 细胞下调。Neihulizumab 可用于类固醇难治性急性移植物抗宿主病 (SR-aGVHD)、银屑病、银屑病关节炎和溃疡性结肠炎的研究。

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Neihulizumab Chemical Structure

Neihulizumab Chemical Structure

CAS No. : 2158362-38-8

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规格 价格 是否有货 数量
1 mg ￥3000
In-stock
5 mg ￥9000
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Neihulizumab 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Neihulizumab (ALTB-168) is an immune checkpoint agonistic antibody that binds to human CD162 (PSGL-1), leading to downregulation of activated T-cells. Neihulizumab can be uesd for steroid-refractory acute graft-versus-host-disease (SR-aGVHD), psoriasis, psoriatic arthritis and ulcerative colitis research[1].

体外研究
(In Vitro)

Neihulizumab 是一种针对 P-选择素糖蛋白配体-1 (PSGL-1) 的单克隆抗体。Neihulizumab 与人 PSGL-1 结合，从而优先诱导晚期活化 T 细胞的凋亡。在炎症部位，血管内皮表达 P-选择素，活化的 T 细胞与这些部位结合并通过 PSGL-1 的表达迁移。以这种方式，Neihulizumab 被认为靶向活化的 T 细胞并抑制运输到发炎组织部位[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Neihulizumab 相关抗体:
Clinical Trial
CAS 号
性状

液体

颜色

Colorless to light yellow

运输条件

Shipping with dry ice.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Neihulizumab 相关分类

  • 摩尔计算器

  • 稀释计算器

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Neihulizumab2158362-38-8ALTB-168 Anti-PSGL1/CD162 Reference Antibody (neihulizumab)ALTB168ALTB 168Apoptosishumanised monoclonal antibodyCD162PSGL-1SR-aGVHDpsoriasispsoriatic arthritis and ulcerative colitisT-cellsInhibitorinhibitorinhibit

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