1. Membrane Transporter/Ion Channel Neuronal Signaling
  2. Calcium Channel
  3. Nemadipine-A

Nemadipine-A 是 EGL-19 Ca2+ 通道 (Ca2+ channel) 的特异性抑制剂。Nemadipine-A 是一种细胞渗透性 L 型钙通道抑制剂,可使对 TRAIL 抗性的癌细胞对该配体敏感。

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Nemadipine-A Chemical Structure

Nemadipine-A Chemical Structure

CAS No. : 54280-71-6

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5 mg ¥1426
3 - 4 周
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  • 生物活性

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  • 参考文献

生物活性

Nemadipine-A is a specific inhibitor of the EGL-19 L-type Ca2+ channel[1]. Nemadipine-A, a cell-permeable L-type calcium channel inhibitor, sensitizes TRAIL-resistant cancer cells to this ligand[2].

体外研究
(In Vitro)

Nemadipine-A is a specific and highly effective inhibitor of EGL-19. Nemadipine-A (µM) is sufficient to abolish the enhanced level of paralysis observed in egl-19(ad695); crIs4 mutants[1].
Nemadipine-A strongly potentiates TRAIL-induced apoptosis in TRAIL-resistant lung cancer cells via the down-regulation of the anti-apoptotic protein survivin[2]. Nemadipine-A sensitizes H1299 lung cancer cells towards TRAIL-induced cytotoxicity[2]. Combination of Nemadipine-A (20 μM) with TRAIL (20 ng/mL) induces caspase-mediated apoptotic cell death[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[2]

Cell Line: H1299 lung adenocarcinoma cells
Concentration: 0, 5, 10, 20, and 30 μM
Incubation Time: 8 hours
Result: H1299 cells were resistant to the apoptotic effects of TRAIL, but the co-administration of Nemadipine-A and TRAIL in these cells resulted in notably increased cytotoxicity in a dose-dependent manner.

Western Blot Analysis[2]

Cell Line: H1299 cells
Concentration: 20 μM
Incubation Time: 8 hours
Result: Co-treated with TRAIL and Nemadipine-A (T/N; 20 ng/mL and 20 μM respectively) induced cell death in H1299 cells.
分子量

419.34

Formula

C19H18F5NO4

CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献
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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Nemadipine-A
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HY-126583
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