2. Neuronal Signaling
  3. Monoamine Oxidase Amyloid-β
  4. Neuroinflammatory-IN-2

Neuroinflammatory-IN-2 是一种有效的抗神经炎症剂，对 MAO-B 的 IC50 为 10.30 μM，25 μM 时能抑制 96.33% 的 Aβ1-42 聚集。Neuroinflammatory-IN-2 在 H2O2 诱导的 PC-12 细胞损伤中具有神经保护作用。Neuroinflammatory-IN-2 还具有生物金属螯合能力、抗氧化活性、抗神经炎症活性和适当的血脑屏障通透性 (BBB)。Neuroinflammatory-IN-2 可用于阿尔兹海默症的研究。

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Neuroinflammatory-IN-2 Chemical Structure

Neuroinflammatory-IN-2 Chemical Structure

CAS No. : 2361384-14-5

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Neuroinflammatory-IN-2 相关抗体

Top Publications Citing Use of Products

查看 Monoamine Oxidase 亚型特异性产品:

查看所有亚型
MAO-A MAO-B

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Neuroinflammatory-IN-2 is a potent anti-neuroinflammatory agent with an IC50 value of 10.30 μM for MAO-B, and 96.33% inhibition of Aβ1-42 aggregation at 25 μM. Neuroinflammatory-IN-2 has neuroprotective activity in H2O2-induced PC-12 cell injury. Neuroinflammatory-IN-2 also has biometal chelating abilities, antioxidant activity, anti-neuroinflammatory activity and appropriate BBB permeability. Neuroinflammatory-IN-2 can be used for researching Alzheimer’s disease[1].

IC50 & Target[1]

MAO-B

10.30 μM (IC50)

体外研究
(In Vitro)

Neuroinflammatory-IN-2 (compound 7i) (1 and 10 μM) dramatically increases the viability of H2O2-treated PC-12 cells by 70.2% and 81.6% at 1 and 10 μM, respectively[1].
Neuroinflammatory-IN-2 (0.5, 2.5 and 10.0 μM) inhibits NO expression in LPS-stimulated BV-2 cells by 32.4%, 46.7% and 57.2% at the concentration of 0.5, 2.5 and 10.0 μM respectively; and inhibits TNF-α by 35.8%, 53.1% and 76.5%, respectively[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Neuroinflammatory-IN-2 相关抗体:
分子量

422.49

Formula

C25H27FN2O3
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Neuroinflammatory-IN-2 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Neuroinflammatory-IN-22361384-14-5Monoamine OxidaseAmyloid-βMAOβ-amyloid peptideAβAbetaAlzheimer’s diseaseneuroprotectiveneuroinflammatoryPC-12BBBantioxidantbiometal chelatingInhibitorinhibitorinhibit

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