2. Apoptosis
  3. Apoptosis
  4. Nimustine

Nimustine 是一种亚硝基脲类烷基化剂。Nimustine 诱导细胞凋亡，激活 DNA 损伤以及 MAPK 信号通路。Nimustine 具有抗癌效应，可用于癌症的研究。

在相同的摩尔浓度下，化合物盐形式与游离形式有相同的生物活性，但盐形式 Nimustine hydrochloride 通常具有更好的水溶性和稳定性。

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Nimustine Chemical Structure

Nimustine Chemical Structure

CAS No. : 42471-28-3

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Nimustine 的其他形式现货产品:

Customer Review

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Nimustine 相关抗体

Top Publications Citing Use of Products

MCE 顾客使用本产品发表的 1 篇科研文献

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Nimustine is a nitrosourea alkylating agent. Nimustine induces cell apoptosis, and activates DNA damage response and MAPK signaling. Nimustine shows anti-cancer effects, it can be used for the research of cancer[1][2].

体外研究
(In Vitro)

Nimustine (50 μM; 72-120 h) causes cell death by inducing cell apoptosis[1].
Nimustine (50 μM; 24-96 h) activates the DNA damage response pathway[1].
Nimustine (50 μM; 24-120 h) activates MAPK signaling in glioma cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Nimustine 相关抗体:

Apoptosis Analysis[1]

Cell Line: LN-229 cell line
Concentration: 50 μM
Incubation Time: 72-120 hours
Result: Time-dependently induced apoptosis.

Western Blot Analysis[1]

Cell Line: LN-229 and glioma cell lines
Concentration: 50 μM
Incubation Time: 24-120 hours
Result: Induced cleavage of caspase-8 and -9 and the effector caspase-3. Increased phosphorylation of ERK kinase and H2AX. Decreased phosphorylation of JNK
体内研究
(In Vivo)

Nimustine (15 four times a week and 30 mg/kg twice with an interval of 2 weeks; i.v.) effectively inhibits tumor growth and the higher dose is more effective[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female C3H/HeN mice with solid FM3A tumors[2]
Dosage: 15 and 30 mg/kg
Administration: Intravenous injection; 15 (4 times a week) and 30 mg/kg (twice with an interval of 2 weeks)
Result: The intermittent large-dose injections resulted in better inhibition of tumor growth than did the fractionated small-dose injections.
Clinical Trial
分子量

272.69

Formula

C9H13ClN6O2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Nimustine 相关分类

  • 摩尔计算器

  • 稀释计算器

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Nimustine42471-28-3Apoptosisnitrosourea alkylatingapoptosisDNA damageMAPKanti-cancerLN-229gliomamiceFM3AInhibitorinhibitorinhibit

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