2. Apoptosis Cell Cycle/DNA Damage MAPK/ERK Pathway Immunology/Inflammation
  3. Apoptosis DNA Alkylator/Crosslinker DNA/RNA Synthesis p38 MAPK JNK AP-1
  4. Nimustine

Nimustine 是一种烷化剂，可诱导 DNA 双链断裂 (DSB) 和链间交联 (ICL)，从而激活 DNA 损伤反应 (DDR) 信号通路。Nimustine 可激活 p38 MAPK/JNK 信号通路，并表现出抗肿瘤活性。

在相同的摩尔浓度下，化合物盐形式与游离形式有相同的生物活性，但盐形式 Nimustine hydrochloride 通常具有更好的水溶性和稳定性。

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Nimustine

Nimustine Chemical Structure

CAS No. : 42471-28-3

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Nimustine 的其他形式现货产品:

Customer Review

Other Forms of Nimustine:

Nimustine 相关抗体

Top Publications Citing Use of Products

MCE 顾客使用本产品发表的 1 篇科研文献

查看 p38 MAPK 亚型特异性产品:

查看所有亚型
p38 MAPK p38α p38β MAPK13 p38δ p38γ

查看 JNK 亚型特异性产品:

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JNK1 JNK2 JNK3 JNK

查看 AP-1 亚型特异性产品:

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c-Fos FosB Fra1/FOSL1 Fra2/FOSL2 c-Jun

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Nimustine is an alkylating agent, which induces DNA double-strand breaks (DSBs) and inter-strand crosslinks (ICLs), thereby activating the DNA damage response (DDR) signaling pathway. Nimustine activates p38 MAPK/JNK signaling pathway, and exhibits antitumor activity[1][2].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
SF-126 IC50
310 μM
Compound: ACNU
Cytotoxicity against human SF126 cells expressing low level of AGT assessed as cell survival after 24 hrs by CCK8 assay in presence of O6-BG
Cytotoxicity against human SF126 cells expressing low level of AGT assessed as cell survival after 24 hrs by CCK8 assay in presence of O6-BG
[PMID: 27041398]
SF-126 IC50
320 μM
Compound: ACNU
Cytotoxicity against human SF126 cells expressing low level of AGT assessed as cell survival after 24 hrs by CCK8 assay
Cytotoxicity against human SF126 cells expressing low level of AGT assessed as cell survival after 24 hrs by CCK8 assay
[PMID: 27041398]
SF-126 IC50
360 μM
Compound: ACNU
Cytotoxicity against AGT-deficient human SF126 cells assessed as reduction in cell viability pretreated with O6-BG for 2 hrs followed by addition of compound measured after 24 hrs by CCK8 assay
Cytotoxicity against AGT-deficient human SF126 cells assessed as reduction in cell viability pretreated with O6-BG for 2 hrs followed by addition of compound measured after 24 hrs by CCK8 assay
[PMID: 28197307]
SF-126 IC50
450 μM
Compound: ACNU
Cytotoxicity against AGT-deficient human SF126 cells assessed as reduction in cell viability measured after 24 hrs by CCK8 assay
Cytotoxicity against AGT-deficient human SF126 cells assessed as reduction in cell viability measured after 24 hrs by CCK8 assay
[PMID: 28197307]
U-87MG ATCC IC50
0.84 μM
Compound: Nimustine
Cytotoxicity against human U87MG cells after 72 hrs by MTT assay
Cytotoxicity against human U87MG cells after 72 hrs by MTT assay
[PMID: 20184290]
体外研究
(In Vitro)

Nimustine (50 μM, 72 h) 激活 caspase 和 AP-1，上调 bim 的表达，促进 c-Jun 的磷酸化，诱导细胞 LN-229 凋亡[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Nimustine 相关抗体:

Apoptosis Analysis[1]

Cell Line: LN-229 cell line
Concentration: 50 μM
Incubation Time: 72-120 hours
Result: Time-dependently induced apoptosis.

Western Blot Analysis[1]

Cell Line: LN-229
Concentration: 50 μM
Incubation Time: 24-120 hours
Result: Increased the expressions of cleaved of bim and caspase-3/8/9.
体内研究
(In Vivo)

Nimustine (15-30 mg/kg, iv, every two weeks for 2 doses, or once weekly for 4 doses) 与放射疗法联合使用可抑制肿瘤生长，但对小鼠有毒性[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female C3H/HeN mice with solid FM3A tumors[2]
Dosage: 15 and 30 mg/kg
Administration: iv, every two weeks for 2 doses (30 mg/kg), or once weekly for 4 doses (15 mg/kg)
Result: Inhibited tumor growth. Caused weight loss and white blood cell (WBC) depression.
Clinical Trial
分子量

272.69

Formula

C9H13ClN6O2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Nimustine 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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× = ×
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Nimustine42471-28-3ApoptosisDNA Alkylator/CrosslinkerDNA/RNA Synthesisp38 MAPKJNKAP-1c-Jun N-terminal kinaseActivator Protein 1nitrosourea alkylatingapoptosisDNA damageMAPKanti-cancerLN-229gliomamiceFM3AInhibitorinhibitorinhibit

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