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NNMTi 

目录号: HY-131042
产品使用指南

NNMTi 是一种有效的烟酰胺 N -甲基转移酶 (NNMT) 的抑制剂 (IC50=1.2 μM),可选择性地结合 NNMT 底物结合位点残基。NNMTi 能促进体外成肌细胞分化,增强老年小鼠肌肉干细胞融合和再生能力。

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NNMTi Chemical Structure

NNMTi Chemical Structure

CAS No. : 42464-96-0

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Description

NNMTi is a potent nicotinamide N-methyltransferase (NNMT) inhibitor (IC50=1.2 μM) and selectively binds to the NNMT substrate-binding site residues[1]. NNMTi  promotes myoblast differentiation in vitro and enhances fusion and regenerative capacity of muscle stem cells (muSCs) in aged mice[2].

In Vitro

NNMTi (10-30 µM; 96 hours) produces a concentration-related increase in myoblast differentiation on C2C12 myoblast differentiation. 30 µM NNMTi results in 18% MHC-positive myotube nuclei, representing a 45% increase in the extent of myoblast differentiation compared to untreated differentiating myoblasts (12% MHC-positive myotube nuclei)[2].

In Vivo

NNMTi (subcutaneous (SC) injection; 5 mg/kg and 10 mg/kg; 2 weeks (1 week pre-injury and 1 week post-injury)) has an effect on muscle regeneration after injury, it results in 60% and 75% higher incidence of proliferating/active muSCs at 5 mg/kg and 10 mg/kg, respectively. The relative numbers of fibers with an EdU+ myonucleus increased 40% and 48% with NNMTi treatment at 5 mg/kg and 10 mg/kg, respectively. The odds ratio of fused myonuclei for control are 0.58 and 0.53 times the odds at the low and high NNMTi dose, respectively[1].
NNMTi (subcutaneous injection; 10 mg/kg; 1 week) produces no systemic toxicity in mice, the levels of the glucose, cholesterol, plasma proteins, and electrolytes between control and NNMTi-treated samples show no difference in mice. 1-week post-injury daily repeat-dosing of NNMTi is well tolerated with no untoward systemic toxicity or behavioral implications in aged mice[1].

Molecular Weight

286.11

Formula

C₁₀H₁₁IN₂

CAS No.

42464-96-0

SMILES

C[N+]1=C2C=CC=C(N)C2=CC=C1.[I-]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

NNMTiOthersmuSCNNMTfusionregenerativemuscle stem cellInhibitorinhibitorinhibit

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NNMTi
目录号:
HY-131042
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