2. Immunology/Inflammation
  3. NOD-like Receptor (NLR) Interleukin Related
  4. NOD2 agonist 4

NOD2 agonist 4 (Compound 12b) 是一种强效的 NOD2 激动剂，其 EC50 值为 44.1 nM。NOD2 agonist 4 能够单独或与 Lipopolysaccharide (LPS) (HY-D1056) 联合作用，促使外周血单核细胞(PBMCs) 产生细胞因子 (MCP-1、IL-6 和 IL-8)。NOD2 agonist 4 可用于研究针对 NOD2 的免疫调节剂或疫苗佐剂。

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NOD2 agonist 4

NOD2 agonist 4 Chemical Structure

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NOD2 agonist 4 相关抗体

Top Publications Citing Use of Products

查看 NOD-like Receptor (NLR) 亚型特异性产品:

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NLRP3 NLRP1 NOD1 NOD2

查看 Interleukin Related 亚型特异性产品:

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IL-1 IL-2 IL-3 IL-4 IL-5 IL-6 IL-8 IL-10 IL-12 IL-13 IL-15 IL-17 IL-23 IL-7 IL-33 IL-22

  • 生物活性

  • 纯度 & 产品资料

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生物活性

NOD2 agonist 4 (Compound 12b) is a potent NOD2 agonist with an EC50 of 44.1 nM. NOD2 agonist 4 induces cytokine production (MCP-1, IL-6 and IL-8) in peripheral blood mononuclear cells (PBMCs), both alone and in combination with Lipopolysaccharide (LPS) (HY-D1056). NOD2 agonist 4 can be used for the studies of NOD2-targeted immunomodulator or vaccine adjuvant[1].
IC50 & Target[1]

NOD2

44.1 nM (EC50)

IL-6

 

IL-8

 

分子量

585.47

Formula

C28H39FeN3O7
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

NOD2 agonist 4 相关分类

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

NOD2 agonist 4NOD-like Receptor (NLR)Interleukin RelatedILFerroceneDesmuramylpeptidesNOD2 AgonistsImmunomodulationInhibitorinhibitorinhibit

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