2. Inhibitory Antibodies
  3. Orilanolimab

Orilanolimab  (Synonyms: SYNT001)

目录号: HY-P99791 纯度: 98.45%
COA

摩尔计算器

Orilanolimab (SYNT001) 是一种人源化、去免疫化和阻断 FcRn 的单克隆抗体。Orilanolimab 阻断 FcRn 和 IgG 分子的 Fc 部分之间的相互作用。Orilanolimab 阻碍 IgG IC 激活 FcRn 介导的适应性免疫功能。Orilanolimab 可破坏与 IgG 稳态和先天性和适应性免疫相关。

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Orilanolimab Chemical Structure

Orilanolimab Chemical Structure

CAS No. : 2066544-85-0

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规格 价格 是否有货 数量
1 mg ￥4000
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Orilanolimab 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Orilanolimab (SYNT001) is a humanized, de-immunized and FcRn-blocking monoclonal antibody. Orilanolimab blocks the interaction between FcRn and the Fc portion of IgG molecules. Orilanolimab impedes IgG IC activation of the FcRn-mediated adaptive immune function. And Orilanolimab disrupts the associated pathways related to IgG homeostasis and innate and adaptive immunity[1][2].

同型

Human IgG4 kappa
推荐同型对照抗体
种属

Chimeric
IC50 & Target

Interaction between FcRn and IgG[1]
体外研究
(In Vitro)

Orilanolimab (10nM、50nM和100nM；48小时) 抑制 B2MTG/TGFCGRTTG/TGFcgrt-/- 小鼠的 CD11c＜sup＞+IFN-γ 的产生[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Orilanolimab 相关抗体:
体内研究
(In Vivo)

Orilanolimab (20mg/kg；静脉注射) 显著降低小鼠模型中HuLys11的血浆浓度[1]。
Orilanolimab (10-100 mg/kg；静脉注射；每5周一次) 导致IgG食蟹猴总循环水平的剂量依赖性和特异性降低[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
CAS 号
性状

液体

颜色

Colorless to light yellow

运输条件

Shipping with dry ice.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料

纯度: 98.45%

COA (150 KB)

抗体抑制剂使用指南 (1152 KB)
参考文献

  • 摩尔计算器

  • 稀释计算器

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Orilanolimab2066544-85-0SYNT001SYNT 001SYNT-001OthersInhibitorinhibitorinhibit

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