2. Inhibitory Antibodies
  3. Pabinafusp alfa

Pabinafusp alfa  (Synonyms: JR-141)

目录号: HY-P99797 纯度: 97.49%
COA

摩尔计算器

Pabinafusp alfa (JR-141) 是转铁蛋白受体靶向抗体，由 Iduronate 2-sulfatase (HY-P76399) 和抗人转铁蛋白受体抗体组成。Pabinafusp alfa 具有血脑透过性，阻止硫酸肝素 (HS) 在粘多糖病 II (MPS II) 小鼠的中枢神经系统中的沉积。Pabinafusp alfa 改善小鼠学习能力，并预防中枢神经系统神经元损伤。

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Pabinafusp alfa Chemical Structure

Pabinafusp alfa Chemical Structure

CAS No. : 2140211-48-7

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1 mg ￥6000
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Pabinafusp alfa 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Pabinafusp alfa (JR-141) is a transferrin receptor-targeting antibody consisting of Iduronate 2-sulfatase (HY-P76399) and an anti-human transferrin receptor antibody. Pabinafusp alfa is blood-brain permeable and prevents heparan sulfate (HS) deposition in the central nervous system of mucopolysaccharidosis II (MPS II) mice. Pabinafusp alfa improves learning and prevents central nervous system neuronal damage in mice[1].

IC50 & Target

Transferrin receptor[1]
体内研究
(In Vivo)

Pabinafusp alfa (0.1-2 mg/kg；静脉注射；每周一次，持续 36 周) 剂量依赖性地预防 MPS II 小鼠模型的神经组织病理学变化并改善神经缺陷[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Mouse model of MPS II[1]
Dosage: 0.1 mg/kg, 0.5 mg/kg, and 2 mg/kg
Administration: Intravenous injection; once weekly for 36 weeks
Result: Dose-dependently decreases the level of heparan sulfate (HS) in the brain and cerebrospinal fluid (CSF), as well as decreasing the substrate concentrations.
Recovered spontaneous alterations in a dose-dependent manner, indicating an impaired working memory prevented.
Clinical Trial
CAS 号
性状

液体

颜色

Colorless to light yellow

运输条件

Shipping with dry ice.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Pabinafusp alfa2140211-48-7JR-141JR141JR 141Inhibitorinhibitorinhibit

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