1. Protein Tyrosine Kinase/RTK
    Autophagy
  2. VEGFR
    c-Kit
    PDGFR
    Autophagy
    FGFR
  3. Pazopanib-d6

Pazopanib-d6 (Synonyms: GW786034-d6)

目录号: HY-10208S
产品使用指南

Pazopanib-d6 (GW786034-d6) 是 Pazopanib 的氘代物。Pazopanib (GW786034) 是多靶点抑制剂,抑制 VEGFR1VEGFR2VEGFR3PDGFRβc-KitFGFR1c-FmsIC50分别为10,30,47,84,74,140,146 nM。

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Pazopanib-d6 Chemical Structure

Pazopanib-d6 Chemical Structure

CAS No. : 1219592-01-4

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规格 是否有货
1 mg
询价
5 mg
询价

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Pazopanib-d6 (GW786034-d6) is the deuterium labeled Pazopanib. Pazopanib (GW786034) is a novel multi-target inhibitor of VEGFR1, VEGFR2, VEGFR3, PDGFRβ, c-Kit, FGFR1, and c-Fms with IC50s of 10, 30, 47, 84, 74, 140 and 146 nM, respectively.

体外研究
(In Vitro)

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

443.55

Formula

C21H17D6N7O2S

CAS 号
中文名称

帕唑帕尼 d6

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

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产品名称:
Pazopanib-d6
目录号:
HY-10208S
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