pep2-SVKI 

pep2-SVKI is a selective peptide inhibitor. pep2-SVKI inhibits the binding of AMPA-type glutamate receptor (GluA2) (C-terminal PDZ site) to glutamate receptor interacting protein (GRIP), AMPA receptor binding protein (ABP), and C-kinase interacting protein (PICK1). pep2-SVKI increases the amplitude of AMPA receptor-mediated currents and blocks long-term depression (LTD). pep2-SVKI can be used to study neurological diseases^[1][2][3][4].

pep2-SVKI (1 mM) 可降低星状细胞突触膜中 -60 mV 和 +40 mV 处的 (微型兴奋性突触后电流) mEPSC 幅度^[1]。

pep2-SVKI (100 μM) 可增加海马 CA1 区神经元中 AMPAR 介导的 (兴奋性突触后电流) EPSC^[2]。

pep2-SVKI (100 μM) 可抑制海马 CA1 区神经元中 (蛋白激酶 C) PKC 依赖的 LTD 表达^[2]。

pep2-SVKI 可增加 100 μM AMPA 诱导的用 (放射性标记的去甲肾上腺素) [³H]NA 预标记的海马突触体中氚的释放，并增强 AMPA 诱导的大鼠海马突触体中 [³H]NA 的释放^[3]。

pep2-SVKI 可增加大鼠海马突触体膜上暴露的 AMPA 受体数量^[3]。

pep2-SVKI 可消除控制 [³H]NA 释放的 AMPA 受体对 Cyclothiazide (HY-101165) 的敏感性^[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

1284.46

C₆₀H₉₃N₁₃O₁₈

328944-75-8

Tyr-Asn-Val-Tyr-Gly-Ile-Glu-Ser-Val-Lys-Ile

YNVYGIESVKI

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Liu SJ, et al. Subunit interaction with PICK and GRIP controls Ca2+ permeability of AMPARs at cerebellar synapses. Nat Neurosci. 2005 Jun;8(6):768-75.  [Content Brief]

  [2]. Daw MI, et al. PDZ proteins interacting with C-terminal GluR2/3 are involved in a PKC-dependent regulation of AMPA receptors at hippocampal synapses. Neuron. 2000 Dec;28(3):873-86.  [Content Brief]

  [3]. Pittaluga A, et al. Trafficking of presynaptic AMPA receptors mediating neurotransmitter release: neuronal selectivity and relationships with sensitivity to cyclothiazide. Neuropharmacology. 2006 Mar;50(3):286-96.  [Content Brief]