2. Protein Tyrosine Kinase/RTK Epigenetics TGF-beta/Smad
  3. SHP2 PKC
  4. PF-03622905

PF-03622905 是一种有效的 ATP 竞争性 PKC 抑制剂，对 PKCα、PKCβI、PKCβII、PKCγ 和 PKCθ 的 IC50 分别为 5.6 nM、14.5 nM、13 nM、37.7 nM 和 74.1 nM。PF-03622905 对 PKC 的特异性高于其他蛋白激酶。

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PF-03622905 Chemical Structure

PF-03622905 Chemical Structure

CAS No. : 1072100-15-2

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PF-03622905 相关抗体

Top Publications Citing Use of Products

查看 PKC 亚型特异性产品:

查看所有亚型
PKC PKCα PKCβ PKCγ PKCδ PKCε PKCη PKCζ PKCθ PKCμ PKCι

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

PF-03622905 is a potent and ATP-competitive PKC inhibitor with IC50s of 5.6 nM, 14.5 nM, 13 nM, 37.7 nM, and 74.1 nM for PKCα, PKCβI, PKCβII, PKCγ, and PKCθ, respectively. PF-03622905 shows high specificity for PKC over other protein kinases[1].

IC50 & Target[1]

PKCα

5.6 nM (IC50)

PKCβI

14.5 nM (IC50)

PKCβII

13 nM (IC50)

PKCγ

37.7 nM (IC50)

PKCθ

74.1 nM (IC50)

体外研究
(In Vitro)

PF-03622905 causes concentration-dependent inhibition of phospho-ERK1/2 formation, interleukin 8 release, and phospho-SHP2 levels with an IC50 value 0.15 μM, 0.16 μM, and 35 nM, respectively[1].
PF-03622905 shows low cytotoxicity at 1 μM against human umbilical vein endothelial cells with remaining cell viability at 83.3% viable[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

PF-03622905 相关抗体:
分子量

469.58

Formula

C24H35N7O3
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

PF-03622905 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PF-036229051072100-15-2PF03622905PF 03622905SHP2PKCSrc homology phosphatase 2PTPN11Protein kinase CPKCαPKCβIPKCβIIPKCγPKCθIL-8Inhibitorinhibitorinhibit

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产品名称：
PF-03622905
目录号：
HY-139466
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