1. Membrane Transporter/Ion Channel
  2. Sodium Channel
  3. PF-06305591 dihydrate

PF-06305591 dihydrate 

目录号: HY-114301A 纯度: >99.0%
产品使用指南

PF-06305591 dihydrate 是一种有效的、高选择性的电压门控钠通道 NaV1.8 的阻断剂,其IC50 值为15 nM。具有良好的临床前体外ADME (吸收、分布、代谢和排泄) 和安全性。

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PF-06305591 dihydrate Chemical Structure

PF-06305591 dihydrate Chemical Structure

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Description

PF-06305591 dihydrate is a potent and highly selective voltage gated sodium channel NaV1.8 blocker, with an IC50 of 15 nM. An excellent preclinical in vitro ADME and safety profile[1].

IC50 & Target

IC50: 15 nM (NaV1.8)[1].

In Vitro

PF-06305591 (compound 9) has a highly attractive profile with respect to NaV selectivity, hERG activity, passive permeability and in vitro metabolic stability[1].

In Vivo

PF-06305591 (compound 9) has good rat bioavailability. PF-06305591 offers the possibility of investigating higher IC50 multiples of Nav1.8 blockade in the clinic, and therefore a more thorough evaluation of the role of NaV1.8 in the treatment of pain[1].

Molecular Weight

310.39

Formula

C₁₅H₂₆N₄O₃

SMILES

CC(C)(C)C1=CC=C(NC([C@H]([C@@H](C)C(N)=O)N)=N2)C2=C1.[H]O[H].[H]O[H]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
In solvent -80°C 6 months
  -20°C 1 month
References

Purity: >99.0%

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

PF-06305591 dihydrateSodium ChannelNa channelsNa+ channelsNaV1.8painInhibitorinhibitorinhibit

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产品名称:
PF-06305591 dihydrate
目录号:
HY-114301A
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