2. Protein Tyrosine Kinase/RTK PI3K/Akt/mTOR MAPK/ERK Pathway Stem Cell/Wnt Immunology/Inflammation GPCR/G Protein Apoptosis
  3. Btk Akt mTOR p38 MAPK ERK CCR Apoptosis
  4. PLS-123

LPS-123 是一种共价不可逆的 BTK 抑制剂，其 IC50 < 5 nM。LPS-123 同时抑制 BTK 在 Tyr551 的催化活性和 Tyr223 的自激活。LPS-123 抑制 AKT/mTOR 和 MAPK 信号通路的磷酸化、PLCγ2、ERK1/2、p38、AKT 和 mTOR 的激活、阻断 CCL3 和 CCL4 趋化因子的产生。LPS-123 对多种 B 细胞淋巴瘤细胞系具有显著的抗增殖活性，通过 caspase 依赖性途径有效诱导细胞凋亡 (apoptosis)。LPS-123 在 OCI-Ly7 异种移植模型中表现出显著的抗肿瘤活性。LPS-123 可用于研究淋巴瘤。

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PLS-123

PLS-123 Chemical Structure

CAS No. : 1431727-04-6

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PLS-123 相关抗体

Top Publications Citing Use of Products

查看 Akt 亚型特异性产品:

查看所有亚型
Akt Akt1 Akt2 Akt3

查看 mTOR 亚型特异性产品:

查看所有亚型
mTOR mTORC1 mTORC2

查看 p38 MAPK 亚型特异性产品:

查看所有亚型
p38 MAPK p38α p38β MAPK13 p38δ p38γ

查看 ERK 亚型特异性产品:

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ERK ERK1 ERK2 ERK5 ERK8

查看 CCR 亚型特异性产品:

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CCR1 CCR2 CCR3 CCR4 CCR5 CCR6 CCR7 CCR8 CCR9

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

LPS-123 is a covalently irreversible BTK inhibitor with an IC50 of < 5 nM. LPS-123 simultaneously inhibits the catalytic activity of BTK at Tyr551 and its self-activation at Tyr223. LPS-123 inhibits phosphorylation of the AKT/mTOR and MAPK signaling pathways, activation of PLCγ2, ERK1/2, p38, AKT, and mTOR, and blocks the production of CCL3 and CCL4 chemokines. LPS-123 exhibits significant anti-proliferative activity against various B-cell lymphoma cell lines and effectively induces apoptosis via a caspase-dependent pathway. LPS-123 also demonstrates significant antitumor activity in the OCI-Ly7 xenograft model. LPS-123 can be used for lymphoma research[1].

分子量

617.58

Formula

C31H26F3N7O4
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

PLS-123 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PLS-1231431727-04-6PLS123PLS 123BtkAktmTORp38 MAPKERKCCRApoptosisBruton tyrosine kinasePKBProtein kinase BMammalian target of RapamycinExtracellular signal regulated kinasesCC chemokine receptorInhibitorinhibitorinhibit

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产品名称：
PLS-123
目录号：
HY-120406
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