2. PROTAC Metabolic Enzyme/Protease
  3. PROTACs Glutaminase
  4. PROTAC TG2 degrader-2

PROTAC TG2 degrader-2 (compound 7) 是靶向 Transglutaminase 2 (TG2) 具有选择性的竞争性降解剂, Kd 值 > 100 μM。PROTAC TG2 degrader-2 抑制卵巢癌细胞迁移，降低细胞内的 TG2 水平。PROTAC TG2 degrader-2 可用于卵巢癌研究。

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PROTAC TG2 degrader-2 Chemical Structure

PROTAC TG2 degrader-2 Chemical Structure

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

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Customer Review

PROTAC TG2 degrader-2 相关抗体

Top Publications Citing Use of Products

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von Hippel-Lindau (VHL) Cereblon MDM2 cIAP1

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

PROTAC TG2 degrader-2 (compound 7) is a selective, competitive degrader targeting Transglutaminase 2 (TG2), with Kd > 100 μM. PROTAC TG2 degrader-2 inhibits the cell migration and decreases the level of TG2 in ovarian cancer cells. PROTAC TG2 degrader-2 can be used for ovarian cancer study[1].

IC50 & Target

> 100 μM (TG2)
体外研究
(In Vitro)

PROTAC TG2 degrader-2 (Compound 7) (10 μΜ，高达 24 h) 在伤口愈合试验侵袭迁移试验中抑制 OVCAR5 和 SKOV3 细胞系的迁移[1]。
PROTAC TG2 degrader-2 (10 μΜ) 降低 OVCAR5 和 SKOV3 细胞对纤维连接蛋白的粘附[1]。
PROTAC TG2 degrader-2 (高达 10 μΜ，6 h) 在 OVCAR5 和 SKOV3 细胞中以浓度依赖的方式在 6 h 内降低谷氨酰胺转移酶 (TG2) 的水平[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

PROTAC TG2 degrader-2 相关抗体:

Cell Migration Assay [1]

Cell Line: OVCAR5 and SKOV3 cells
Concentration: 10 μΜ
Incubation Time: Wound-healing assay: 24 h (OVCAR5 cells) and 12 h (OVCAR5 cells) (SKOV3 cells)
Result: Inhibited the migration.

Western Blot Analysis[1]

Cell Line: OVCAR5 and SKOV3 cells
Concentration: 0.1, 1 and 10 μΜ (OVCAR5 cells), 1 and 10 μΜ (OVCAR5 cells) (SKOV3 cells)
Incubation Time: 6 h and 24 h
Result: Reduced the level of TG2.
分子量

876.08

Formula

C47H57N9O6S
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

PROTAC TG2 degrader-2 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PROTAC TG2 degrader-2PROTACsGlutaminaseOVCAR5SKOV3Ovarian cancerTransglutaminase 2Inhibitorinhibitorinhibit

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产品名称：
PROTAC TG2 degrader-2
目录号：
HY-155102
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