1. Epigenetics
    TGF-beta/Smad
  2. PKC
  3. Psychosine

Psychosine (Synonyms: Galactosylsphingosine)

目录号: HY-136490
产品使用指南

Psychosine (Galactosylsphingosine) 是半乳糖脑苷脂酶 (GALC) 酶的底物,是 Krabbe 病的潜在生物标志物。Psychosine 是一种高度细胞毒性的脂质,能够在多种细胞类型中诱导细胞死亡,且有部分是通过细胞凋亡 (apoptosis) 导致的细胞死亡。Psychosine 还是一种 PKC 抑制剂。

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Psychosine Chemical Structure

Psychosine Chemical Structure

CAS No. : 2238-90-6

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  • 生物活性

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  • 参考文献

生物活性

Psychosine (Galactosylsphingosine), a substrate of the galactocerebrosidase (GALC) enzyme, is a potential biomarker for Krabbe disease[1]. Psychosine is a highly cytotoxic lipid, capable of inducing cell death in a wide variety of cell types including, most relevantly to globoid cell leukodystrophy (GLD), oligodendrocytes. Psychosine causes cell death at least in part via apoptosis. Psychosine also is an inhibitor of PKC[1].

IC50 & Target[2]

PKC

 

体外研究
(In Vitro)

Psychosine, is a substrate of the GALC enzyme that shows promise to aid in the diagnosis and follow-up of at-risk infants identified through newborn screening (NBS)[1]. Psychosine induces pleiotropic effects, including dysfunctions in several cellular pathways[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[2]

Cell Line: Oligodendrocyte cells, M03.13
Concentration: 10, 20, and 40 μM
Incubation Time: 24 hours
Result: Caused cell death at least in part via apoptosis.
分子量

461.63

Formula

C₂₄H₄₇NO₇

CAS 号
中文名称

鞘氨醇半乳糖苷;半乳糖基鞘氨醇

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

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