2. Metabolic Enzyme/Protease GPCR/G Protein MAPK/ERK Pathway Protein Tyrosine Kinase/RTK
  3. Cytochrome P450 Orphan GPCR p38 MAPK FAK
  4. (Rac)-AAA

(Rac)-AAA 是 AAA 的外消旋体。(Rac)-AAA 是 20-HETE 受体的拮抗剂。(Rac)-AAA 可以增加雄激素不敏感前列腺癌细胞中 GPR75 受体的表达。(Rac)-AAA 剂量依赖性地增加 p38 磷酸化。(Rac)-AAA 诱导细胞核中磷酸化-AKT 信号显著降低。(Rac)-AAA 减弱未受刺激细胞核中的 NF-κB 信号。(Rac)-AAA 可以降低膜相关信号强度。(Rac)-AAA 降低 20-HETE 诱导的 FAK 磷酸化。

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(Rac)-AAA

(Rac)-AAA Chemical Structure

CAS No. : 3055022-23-3

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Other Forms of (Rac)-AAA:

(Rac)-AAA 相关抗体

Top Publications Citing Use of Products

查看 Cytochrome P450 亚型特异性产品:

查看所有亚型
CYP1 CYP2 CYP3 CYP4 CYP11 CYP17 Aromatase/CYP19A1 CYP26 CYP51 CYP1A2 CYP2D6 CYP2C9 CYP2C19 CYP3A4 CYP17A1

查看 p38 MAPK 亚型特异性产品:

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p38 MAPK p38α p38β MAPK13 p38δ p38γ

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

(Rac)-AAA is the racemate of AAA. (Rac)-AAA is an antagonist of 20-HETE receptor. (Rac)-AAA can increase the expression of GPR75 receptor in androgen-insensitive prostate cancer cells. (Rac)-AAA dose-dependently increases p38 phosphorylation. (Rac)-AAA induces a significant decrease in the phosphor-AKT signal in nuclei of cells. (Rac)-AAA mitigates the NF-κB signal in unstimulated cell nuclei. (Rac)-AAA can diminish the membrane associated signal intensity. (Rac)-AAA decreases the FAK phosphorylation induced by 20-HETE[1].

分子量

483.55

Formula

C24H39NNa2O6
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

(Rac)-AAA 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(Rac)-AAA3055022-23-3Cytochrome P450Orphan GPCRp38 MAPKFAKCYPsRrphan G protein-coupled receptorPTK2 protein tyrosine kinase 2PTK2Focal adhesion kinaseInhibitorinhibitorinhibit

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