2. Vitamin D Related/Nuclear Receptor
  3. Estrogen Receptor/ERR
  4. (Rac)-ErSO-DFP

(Rac)-ErSO-DFP 是一种 ErSO-DFP 的衍生物和选择性小分子 Erα 生物调节剂。(Rac)-ErSO-DFP 通过过度激活 ERα+ 依赖性的预期未折叠蛋白反应来发挥抗雌激素受体 α 阳性乳腺癌 (包括其抗性肿瘤) 的活性 (摘自专利 WO2022087234A1)。

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(Rac)-ErSO-DFP Chemical Structure

(Rac)-ErSO-DFP Chemical Structure

CAS No. : 2768139-73-5

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Other Forms of (Rac)-ErSO-DFP:

(Rac)-ErSO-DFP 相关抗体

Top Publications Citing Use of Products

查看 Estrogen Receptor/ERR 亚型特异性产品:

查看所有亚型
Estrogen receptor ERα ERβ ERRα ERRβ ERRγ

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

(Rac)-ErSO-DFP is a derivative of ErSO-DFP and a selective small molecule Erα biomodulator. (Rac)-ErSO-DFP againsts ERα+ breast cancer (including resistant tumors) by hyperactiving the Erα-dependent a-UPR (extracted from patent WO2022087234A1)[1].

IC50 & Target

IC50: 35 nM (MCF-7 cells)[1].
体外研究
(In Vitro)

(Rac)-ErSO-DFP (compound 2) (0.001-1 µM; 24 h) maintains potent anticancer activity with IC50 of 35 nM in MCF-7 cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

(Rac)-ErSO-DFP 相关抗体:

Cell Viability Assay[1]

Cell Line: MCF-7 cells
Concentration: 0.001-1 µM
Incubation Time: 24 h
Result: Showed a sustained activity of anticancer with IC50 of 35 nM.
体内研究
(In Vivo)

(Rac)-ErSO-DFP (compound 2) (5 mg/kg; i.v.; 3xq.wk.) shows a sustained activity of againsting ERα+ breast cancer at low doses[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Ovariectomized Nu/J mice (MCF-7 orthotopic tumor model)[1].
Dosage: 5 mg/kg
Administration: Intravenous injection; once-a-week for 3 total doses.
Result: Maintained the ability to regress MCF-7 tumors in a mouse model of ERα+ breast cancer.
分子量

412.35

Formula

C20H17F5N2O2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

(Rac)-ErSO-DFP 相关分类

  • 摩尔计算器

  • 稀释计算器

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(Rac)-ErSO-DFP2768139-73-5Estrogen Receptor/ERRERαresistant tumorsbreast cancerErSO-DFPa-UPRInhibitorinhibitorinhibit

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产品名称：
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目录号：
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