2. Cell Cycle/DNA Damage Apoptosis Anti-infection
  3. DNA/RNA Synthesis Apoptosis Antibiotic
  4. (±)-Dehydroaltenusin

(±)-Dehydroaltenusin 是一种抗生素，是一种选择性真核生物 DNA 聚合酶 α (pol α) 抑制剂，其 IC50 为 0.68 μM。(±)-Dehydroaltenusin 可以从真菌 Alternaria tenuis 中分离得到。(±)-Dehydroaltenusin 竞争性地抑制 DNA 模板引物的活性(Ki: 0.23 μM)，并且非竞争性地抑制 2'-脱氧核糖核苷 5'-三磷酸底物的活性(Ki: 0.18 μM)。(±)-Dehydroaltenusin 可诱导癌细胞 S 期周期停滞和细胞凋亡 (apoptosis)。(±)-Dehydroaltenusin 可用于人类腺癌等癌症研究。

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(±)-Dehydroaltenusin

(±)-Dehydroaltenusin Chemical Structure

CAS No. : 34279-44-2

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(±)-Dehydroaltenusin 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

(±)-Dehydroaltenusin, an antibiotic, is a selective eukaryotic DNA polymerase α (pol α) inhibitor with an IC50 of 0.68 μM. (±)-Dehydroaltenusin can be isolated from fungus Alternaria tenuis. (±)-Dehydroaltenusin competitively inhibits the DNA template primer (Ki: 0.23 μM) and non-competitively suppresses the 2'-deoxyribonucleoside 5'-triphosphate substrate (Ki: 0.18 μM). (±)-Dehydroaltenusin induces the cancer cell S-phase cycle arrest and apoptosis. (±)-Dehydroaltenusin can be used for cancers like human adenocarcinoma research[1].

分子量

288.25

Formula

C15H12O6
CAS 号
结构分类
初始来源

Penicillium verruculosum
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

(±)-Dehydroaltenusin 相关分类

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  • Do most proteins show cross-species activity?

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Keywords:

(±)-Dehydroaltenusin34279-44-2DNA/RNA SynthesisApoptosisAntibioticInhibitorDNA polymerase αPol αAlternaria tenuisHuman adenocarcinomainhibitorinhibit

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